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    PURG purine rich element binding protein G [ Homo sapiens (human) ]

    Gene ID: 29942, updated on 17-Jun-2024

    Summary

    Official Symbol
    PURGprovided by HGNC
    Official Full Name
    purine rich element binding protein Gprovided by HGNC
    Primary source
    HGNC:HGNC:17930
    See related
    Ensembl:ENSG00000172733 MIM:618041; AllianceGenome:HGNC:17930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PURGA; PURGB; PURG-A; PURG-B
    Summary
    The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. [provided by RefSeq, Apr 2016]
    Expression
    Biased expression in brain (RPKM 1.4), testis (RPKM 1.1) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PURG in Genome Data Viewer
    Location:
    8p12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (30995802..31033356, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (31276938..31314481, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30853318..30890872, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene testis expressed 15, meiosis and synapsis associated Neighboring gene uncharacterized LOC105379357 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:30763109-30763340 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1136 Neighboring gene NANOG hESC enhancer GRCh37_chr8:30776396-30776897 Neighboring gene lysophosphatidylglycerol acyltransferase 1 pseudogene 1 Neighboring gene MPRA-validated peak6979 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:30891079-30891600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:30914375-30914876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:30914877-30915376 Neighboring gene WRN RecQ like helicase Neighboring gene SUMO2 pseudogene 16 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:31029565-31030764 Neighboring gene uncharacterized LOC105379358

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif modulates the expression of purine-rich element binding protein G (PURG) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119274

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    purine-rich element-binding protein gamma
    Names
    Pur-gamma

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015508.3NP_001015508.1  purine-rich element-binding protein gamma isoform B

      See identical proteins and their annotated locations for NP_001015508.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) differs in the 3' UTR and coding region compared to variant A. The resulting isoform (B) is shorter and has a distinct C-terminus compared to isoform A. Variants B and D encode the same isoform (B).
      Source sequence(s)
      AC008066, AW170055, AY077841
      Consensus CDS
      CCDS34878.1
      UniProtKB/Swiss-Prot
      Q9UJV8
      Related
      ENSP00000345168.2, ENST00000339382.3
      Conserved Domains (1) summary
      pfam04845
      Location:57290
      PurA; PurA ssDNA and RNA-binding protein
    2. NM_001323311.2NP_001310240.1  purine-rich element-binding protein gamma isoform A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (C) differs in the 5' UTR compared to variant A. Variants A and C encode the same isoform (A).
      Source sequence(s)
      AC084736, AF195513, DR003356
      Consensus CDS
      CCDS6081.1
      UniProtKB/Swiss-Prot
      Q8TE64, Q9UJV8
      Related
      ENSP00000466881.2, ENST00000523392.2
      Conserved Domains (1) summary
      pfam04845
      Location:57321
      PurA; PurA ssDNA and RNA-binding protein
    3. NM_001323312.2NP_001310241.1  purine-rich element-binding protein gamma isoform B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (D) differs in the 5' and 3' UTR and coding region compared to variant A. The resulting isoform (B) is shorter and has a distinct C-terminus compared to isoform A. Variants B and D encode the same isoform (B).
      Source sequence(s)
      AC008066, AC084736, AW170055, AY077841, DR003356
      Consensus CDS
      CCDS34878.1
      UniProtKB/Swiss-Prot
      Q9UJV8
      Conserved Domains (1) summary
      pfam04845
      Location:57290
      PurA; PurA ssDNA and RNA-binding protein
    4. NM_013357.2NP_037489.1  purine-rich element-binding protein gamma isoform A

      See identical proteins and their annotated locations for NP_037489.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) encodes the longer isoform (A). Variants A and C encode the same isoform (A).
      Source sequence(s)
      AF195513
      Consensus CDS
      CCDS6081.1
      UniProtKB/Swiss-Prot
      Q8TE64, Q9UJV8
      Related
      ENSP00000418721.1, ENST00000475541.2
      Conserved Domains (1) summary
      pfam04845
      Location:57321
      PurA; PurA ssDNA and RNA-binding protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      30995802..31033356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      31276938..31314481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)