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    Pen Pendulin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34338, updated on 26-Apr-2024

    Summary

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    Official Symbol
    Penprovided by FlyBase
    Official Full Name
    Pendulinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0287720
    Locus tag
    Dmel_CG4799
    See related
    AllianceGenome:FB:FBgn0287720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2.1; alpha2; alpha2A-Kap; alphaKap2; anon-WO0140519.258; bs29g06.y1; CG4799; Dalpha2; Dimp-alpha2; Dmel\CG4799; DPend; Imp alpha-2; imp alpha2; Imp alpha2; imp-alpha2; Imp-alpha2; impalpha2; Impalpha2; IMPalpha2; importin alpha2/pendulin; importin-alpha; Kap alpha2; Kap-alpha2; Kpna2; l(2)144/1; l(2)k06324; l(2)k14401; mbmB; mbmB[N806]; mbm[B]; oho-31; oho31; Oho31; OHO31; pen; PEN; pen-2; Rch1; rem
    Summary
    Predicted to enable nuclear import signal receptor activity. Involved in several processes, including NLS-bearing protein import into nucleus; germ cell development; and gravitaxis. Located in cytoplasm and nucleus. Is expressed in several structures, including embryonic/larval central nervous system; embryonic/larval lymph gland; extended germ band embryo; imaginal disc; and ring gland. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    31A1-31A2; 2-39 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10056900..10060095)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10056900..10060095)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44875 Neighboring gene Cuticular protein 31A Neighboring gene Serpin 31A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Importin-α2 mediates brain development, learning and memory consolidation in Drosophila. Serway CN, et al. J Neurogenet, 2020 Mar. PMID 31965871
    2. Characterization of a Drosophila phosphorylation-dependent nuclear-localization-signal-binding protein. Cserpán I, et al. Biochem J, 1997 Dec 15. PMID 9396726, Free PMC Article
    3. The overgrown hematopoietic organs-31 tumor suppressor gene of Drosophila encodes an Importin-like protein accumulating in the nucleus at the onset of mitosis. Török I, et al. J Cell Biol, 1995 Jun. PMID 7790349, Free PMC Article
    4. The Biochemistry of Cytoplasmic Incompatibility Caused by Endosymbiotic Bacteria. Chen H, et al. Genes (Basel), 2020 Jul 25. PMID 32722516, Free PMC Article
    5. Transcriptional activity and nuclear localization of Cabut, the Drosophila ortholog of vertebrate TGF-β-inducible early-response gene (TIEG) proteins. Belacortu Y, et al. PLoS One, 2012. PMID 22359651, Free PMC Article

    See all (140) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Importin-alpha2 mediates brain development, learning and memory consolidation in Drosophila.
      Title: Importin-α2 mediates brain development, learning and memory consolidation in Drosophila.
    2. Maternal Nanos inhibits Pendulin-dependent nuclear import to prevent somatic gene expression in the Drosophila germline.
      Title: Maternal Nanos inhibits Importin-α2/Pendulin-dependent nuclear import to prevent somatic gene expression in the Drosophila germline.
    3. Importin-alpha2 is needed for some processes in the development of both the nervous system and the larval musculature
      Title: Drosophila Importin-α2 is involved in synapse, axon and muscle development.
    4. Wnt-activated growth of the postsynaptic membrane is mediated by the synapse-to-nucleus translocation and active nuclear import of Fz2-C via a selective Importin-beta11/alpha2 pathway.
      Title: The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development.
    5. each Imp-alpha protein carries during Drosophila spermatogenesis distinct, albeit overlapping, functions that may involve nuclear import of proteins, microtubule organisation, and other yet unknown processes
      Title: Patterns of importin-alpha expression during Drosophila spermatogenesis.
    6. Imp-alpha 2 protein plays a critical role in Kelch function by regulating its deposition on ring canals during their assembly.
      Title: Importin-alpha 2 is critically required for the assembly of ring canals during Drosophila oogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NLS-bearing protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female germline ring canal formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gravitaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lymph gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pendulin
    Names
    CG4799-PA
    Importin-a2
    Importin-alpha
    Importin-alpha2
    Pen-PA
    alpha-importin
    i
    importin alpha
    importin alpha2
    lethal (2) k06324
    mushroom body miniature B
    mushroom-body-miniature-B
    penduline
    reduced-mushroom-bodies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10056900..10060095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057693.5 → NP_477041.1  pendulin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477041.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52295, Q24431, Q95R96, Q9VL45
      Related
      FBpp0079527
      Conserved Domains (3) summary
      COG5064
      Location:2 → 517
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00044
      Location:70 → 102
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:108 → 140
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52295.2 P52295

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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