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    Ahsa1 activator of Hsp90 ATPase activity 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681996, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ahsa1provided by RGD
    Official Full Name
    activator of Hsp90 ATPase activity 1provided by RGD
    Primary source
    RGD:1589285
    See related
    Ensembl:ENSRNOG00000048981 AllianceGenome:RGD:1589285
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATPase activator activity; Hsp90 protein binding activity; and chaperone binding activity. Predicted to be involved in positive regulation of ATPase activity and protein folding. Predicted to be active in cytosol. Orthologous to human AHSA1 (activator of HSP90 ATPase activity 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 385.0), Heart (RPKM 375.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (112644287..112652290)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (106913296..106921347)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (111296168..111304224)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene NADP-dependent oxidoreductase domain containing 1 Neighboring gene uncharacterized LOC134479236 Neighboring gene VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog Neighboring gene isthmin 2 Neighboring gene uncharacterized LOC134479239 Neighboring gene serine palmitoyltransferase, long chain base subunit 2 Neighboring gene uncharacterized LOC134479238

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. Woodford MR, et al. EMBO J, 2017 Dec 15. PMID 29127155, Free PMC Article
    2. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Woodford MR, et al. Nat Commun, 2016 Jun 29. PMID 27353360, Free PMC Article
    3. Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Panaretou B, et al. Mol Cell, 2002 Dec. PMID 12504007
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of ATP-dependent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    activator of 90 kDa heat shock protein ATPase homolog 1
    Names
    AHA1, activator of heat shock 90kDa protein ATPase homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115034.1 → NP_001108506.1  activator of 90 kDa heat shock protein ATPase homolog 1

      See identical proteins and their annotated locations for NP_001108506.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473982
      UniProtKB/TrEMBL
      B0BN63, M0R811
      Related
      ENSRNOP00000065600.1, ENSRNOT00000075425.2
      Conserved Domains (3) summary
      cd08892
      Location:208 → 333
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
      smart01000
      Location:29 → 158
      Aha1_N; Activator of Hsp90 ATPase, N-terminal
      COG5580
      Location:19 → 337
      COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      112644287..112652290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594356.3 → XP_017449845.1  activator of 90 kDa heat shock protein ATPase homolog 1 isoform X1

      UniProtKB/TrEMBL
      A6JE98
      Conserved Domains (1) summary
      cd08892
      Location:73 → 198
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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