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AHSA1 activator of HSP90 ATPase activity 1 [ Homo sapiens (human) ]

Gene ID: 10598, updated on 10-Jun-2018
Official Symbol
AHSA1provided by HGNC
Official Full Name
activator of HSP90 ATPase activity 1provided by HGNC
Primary source
HGNC:HGNC:1189
See related
Ensembl:ENSG00000100591 MIM:608466; Vega:OTTHUMG00000171539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p38; AHA1; hAha1; C14orf3
Expression
Ubiquitous expression in testis (RPKM 60.3), adrenal (RPKM 41.8) and 25 other tissues See more
Orthologs
See AHSA1 in Genome Data Viewer
Location:
14q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (77457877..77469472)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77924373..77935815)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NADP dependent oxidoreductase domain containing 1 Neighboring gene VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog Neighboring gene isthmin 2 Neighboring gene serine palmitoyltransferase long chain base subunit 2 Neighboring gene RNA, 7SL, cytoplasmic 587, pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding HDA PubMed 
chaperone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
response to stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
Preferred Names
activator of 90 kDa heat shock protein ATPase homolog 1
Names
AHA1, activator of heat shock 90kDa protein ATPase homolog 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321441.1NP_001308370.1  activator of 90 kDa heat shock protein ATPase homolog 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF161440, BC000321, BQ073652, CX786861
    UniProtKB/Swiss-Prot
    O95433
    UniProtKB/TrEMBL
    G3V438
    Related
    ENSP00000451569.1, OTTHUMP00000246371, ENST00000555133.5, OTTHUMT00000414016
    Conserved Domains (1) summary
    cd08892
    Location:73198
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
  2. NM_012111.2NP_036243.1  activator of 90 kDa heat shock protein ATPase homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_036243.1

    Status: VALIDATED

    Source sequence(s)
    AF161440, BC000321, BG432594
    Consensus CDS
    CCDS9863.1
    UniProtKB/Swiss-Prot
    O95433
    Related
    ENSP00000216479.3, OTTHUMP00000246372, ENST00000216479.7, OTTHUMT00000414017
    Conserved Domains (2) summary
    cd08892
    Location:208333
    SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
    smart01000
    Location:29158
    Aha1_N; Activator of Hsp90 ATPase, N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    77457877..77469472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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