Abcc9 ATP binding cassette subfamily C member 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcc9provided by RGD
Official Full Name: ATP binding cassette subfamily C member 9provided by RGD
Primary source: RGD:3787
See related: Ensembl:ENSRNOG00000036960 AllianceGenome:RGD:3787
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sur2
Summary: Enables several functions, including identical protein binding activity; sulfonylurea receptor activity; and syntaxin binding activity. Contributes to cation channel activity. Involved in potassium ion import across plasma membrane; response to ATP; and response to xenobiotic stimulus. Located in T-tubule; acrosomal vesicle; and mitochondrion. Part of inward rectifying potassium channel. Biomarker of Parkinsonism; hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1O; familial atrial fibrillation; and hypertrichotic osteochondrodysplasia Cantu type. Orthologous to human ABCC9 (ATP binding cassette subfamily C member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 467.4), Muscle (RPKM 343.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q44

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (177262848..177386837, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (175531854..175655849, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (176806098..176928540, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lymphedema as first clinical presentation of Cantu Syndrome: reversed phenotyping after identification of gain-of-function variant in ABCC9.
Title: Lymphedema as first clinical presentation of Cantu Syndrome: reversed phenotyping after identification of gain-of-function variant in ABCC9.
Cardiac dysfunction in spontaneously hypertensive old rats is associated with a significant decrease of SUR2 expression.
Title: Cardiac dysfunction in spontaneously hypertensive old rats is associated with a significant decrease of SUR2 expression.
Up-regulation of the KATP channel accelerates repolarization and shortens action potential duration during stress and exercise.
Title: Effects of regular exercise on ventricular myocyte biomechanics and K(ATP) channel function.
D207E of Sue2 increases KATP channel activity by increasing intrinsic stability of the open state, whereas the cluster of Y981S/G985E/M1056I substitutions, as well as R1150Q/R1150W, augmented Mg-nucleotide activation.
Title: Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in K(ATP) channel gain-of-function by differential mechanisms.
In vascular smooth muscle KATP channel subunits Kir6.1 and SUR2B contribute to modify the functionality of this channel in hypertension with age.
Title: Altered KATP Channel Subunits Expression and Vascular Reactivity in Spontaneously Hypertensive Rats With Age.
These data provide insights into the molecular basis by which phosphorylation of SUR2B NBD1 activates KATP channels.
Title: Phosphorylation-dependent changes in nucleotide binding, conformation, and dynamics of the first nucleotide binding domain (NBD1) of the sulfonylurea receptor 2B (SUR2B).
Electrophysiological studies employing SUR2A/Kir6.2-expressing HEK cells showed that increasing endogenous or exogenous Phosphatidylinositol 4,5-bisphosphate diminished the inhibitory effect of Syn-1A on KATP currents.
Title: Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels.
Suggest that the increase in KATP channel subunits, SUR2 and Kir6.1, in the rostral ventrolateral medulla may be responsible for the greater sympathetic outflow and pressor effect of hydroxylamine in Ad-cystathionine beta-synthetase injected rats.
Title: Gene transfer of cystathionine β-synthase into RVLM increases hydrogen sulfide-mediated suppression of sympathetic outflow via KATP channel in normotensive rats.
Results demonstrate differential and highly localized expression pattern of sulphonylurea receptor proteins SUR2A and 2B (SUR1) in rat kidney.
Title: Localization of sulphonylurea receptor proteins SUR2A and SUR2B and/or SUR1 in rat kidney.
Testosterone protect female embryonic heart H9c2 cells against severe metabolic stress by its conversion into metabolites that activate estrogen receptors and up-regulate IES SUR2B.
Title: Testosterone protects female embryonic heart H9c2 cells against severe metabolic stress by activating estrogen receptors and up-regulating IES SUR2B.

Submit: New GeneRIF Correction See all GeneRIFs (42)

General gene information

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Markers

RH139436 (e-PCR)
- UniSTS:221522

BE108803 (e-PCR)
- UniSTS:247898

RH134712 (e-PCR)
- UniSTS:217990

D4Got140 (e-PCR)
- UniSTS:114107

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
contributes_to potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sulfonylurea receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfonylurea receptor activity	IEA Inferred from Electronic Annotation more info
enables sulfonylurea receptor activity	TAS Traceable Author Statement more info	PubMed
enables syntaxin binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in action potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood circulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel diameter maintenance	ISO Inferred from Sequence Orthology more info
involved_in cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular respiration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to ATP	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to chemical stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to potassium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circulatory system development	ISO Inferred from Sequence Orthology more info
involved_in coronary vasculature development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in inorganic cation transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oxygen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to ATP	IEA Inferred from Electronic Annotation more info
involved_in response to ATP	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to ATP	ISO Inferred from Sequence Orthology more info
involved_in response to ATP	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to decreased oxygen levels	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to estrogen	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hydrogen sulfide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to oxygen levels	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to potassium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stress	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in substrate-dependent cell migration, cell contraction	NAS Non-traceable Author Statement more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vascular process in circulatory system	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of inward rectifying potassium channel	IDA Inferred from Direct Assay more info	PubMed
part_of inward rectifying potassium channel	IEA Inferred from Electronic Annotation more info
part_of inward rectifying potassium channel	ISO Inferred from Sequence Orthology more info
part_of inward rectifying potassium channel	TAS Traceable Author Statement more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of potassium ion-transporting ATPase complex	RCA inferred from Reviewed Computational Analysis more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcomere	IEA Inferred from Electronic Annotation more info
located_in sarcomere	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family C member 9

Names: ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; ATP-binding cassette, sub-family C, member 9-like; ATP-binding cassette, subfamily C (CFTR/MRP), member 9; Sulfonylurea receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013040.3 → NP_037172.2 ATP-binding cassette sub-family C member 9

See identical proteins and their annotated locations for NP_037172.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IMV7, Q9JJ67

Related

ENSRNOP00000063326.4, ENSRNOT00000067489.4

Conserved Domains (1) summary

TIGR00957
Location:222 → 1542

MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

177262848..177386837 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107119.2 → XP_038963047.1 ATP-binding cassette sub-family C member 9 isoform X1

UniProtKB/TrEMBL

A6IMV7, Q9JJ67

Conserved Domains (1) summary

TIGR00957
Location:222 → 1542

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
XM_039107120.2 → XP_038963048.1 ATP-binding cassette sub-family C member 9 isoform X1

UniProtKB/TrEMBL

A6IMV7, Q9JJ67

Conserved Domains (1) summary

TIGR00957
Location:222 → 1542

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
XM_039107122.2 → XP_038963050.1 ATP-binding cassette sub-family C member 9 isoform X3

UniProtKB/TrEMBL

Q9JJ67

Conserved Domains (1) summary

TIGR00957
Location:213 → 1533

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
XM_039107124.2 → XP_038963052.1 ATP-binding cassette sub-family C member 9 isoform X4

UniProtKB/TrEMBL

Q9JJ67

Conserved Domains (1) summary

TIGR00957
Location:222 → 1529

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
XM_063285616.1 → XP_063141686.1 ATP-binding cassette sub-family C member 9 isoform X6
XM_063285618.1 → XP_063141688.1 ATP-binding cassette sub-family C member 9 isoform X8
XM_063285617.1 → XP_063141687.1 ATP-binding cassette sub-family C member 9 isoform X7
XM_039107123.2 → XP_038963051.1 ATP-binding cassette sub-family C member 9 isoform X5

UniProtKB/TrEMBL

Q9JJ67

Conserved Domains (1) summary

TIGR00957
Location:222 → 1524

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
XM_039107117.2 → XP_038963045.1 ATP-binding cassette sub-family C member 9 isoform X2

UniProtKB/Swiss-Prot

O89115, Q63563

UniProtKB/TrEMBL

A6IMW1, Q9JJ67

Conserved Domains (1) summary

TIGR00957
Location:222 → 1537

MRP_assoc_pro; multi drug resistance-associated protein (MRP)