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Abcc9 ATP-binding cassette, sub-family C member 9 [ Mus musculus (house mouse) ]

Gene ID: 20928, updated on 30-Sep-2024

Summary

Official Symbol
Abcc9provided by MGI
Official Full Name
ATP-binding cassette, sub-family C member 9provided by MGI
Primary source
MGI:MGI:1352630
See related
Ensembl:ENSMUSG00000030249 AllianceGenome:MGI:1352630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sur2; SUR2A; SUR2B
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Broad expression in heart adult (RPKM 24.1), bladder adult (RPKM 9.3) and 15 other tissues See more
Orthologs
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Genomic context

See Abcc9 in Genome Data Viewer
Location:
6 G2; 6 74.35 cM
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142533592..142648472, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142587862..142702766, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38920 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 8 Neighboring gene STARR-seq mESC enhancer starr_17709 Neighboring gene RIKEN cDNA 5330439B14 gene Neighboring gene STARR-seq mESC enhancer starr_17710 Neighboring gene STARR-positive B cell enhancer ABC_E10416 Neighboring gene predicted gene, 53249 Neighboring gene cytidine monophospho-N-acetylneuraminic acid synthetase Neighboring gene predicted gene, 46981 Neighboring gene sulfotransferase family 6B, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled monoatomic cation transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATPase-coupled transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sulfonylurea receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables sulfonylurea receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within ATP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within action potential IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood circulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel diameter maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac conduction IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_positive_effect cardiac muscle cell contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to ATP IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to ATP IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to calcium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to chemical stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to potassium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within circulatory system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within coronary vasculature development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within defense response to virus ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fibroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inorganic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oxygen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of blood pressure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cation channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to ATP IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ATP ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to decreased oxygen levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to estrogen IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to estrogen IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to hydrogen sulfide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to oxygen levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to peptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to potassium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within vascular process in circulatory system IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of inward rectifying potassium channel IEA
Inferred from Electronic Annotation
more info
 
part_of inward rectifying potassium channel ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcomere IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-binding cassette sub-family C member 9
Names
ATP-binding cassette transporter sub-family C member 9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
sulfonylurea receptor 2
sulfonylurea-binding protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044720.2NP_001038185.1  ATP-binding cassette sub-family C member 9 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (d, also known as SUR2 delta17/39) has the same N- and C-termini but is shorter compared to isoform b. This RefSeq is based on data in PMID: 10224138.
    Source sequence(s)
    AC121611
    UniProtKB/TrEMBL
    E9PUE8
    Related
    ENSMUSP00000107401.2, ENSMUST00000111771.8
    Conserved Domains (4) summary
    TIGR00957
    Location:231525
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03288
    Location:12941533
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    cd03290
    Location:669873
    ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
    cl00549
    Location:9821216
    ABC_membrane; ABC transporter transmembrane region
  2. NM_001310143.2NP_001297072.1  ATP-binding cassette sub-family C member 9 isoform e

    See identical proteins and their annotated locations for NP_001297072.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two exons in the 3' coding region, compared to variant 2. It encodes isoform e (also known as SUR2 delta17/40), which lacks an internal in-frame segment and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC121611
    Conserved Domains (1) summary
    TIGR00957
    Location:231530
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  3. NM_001410414.1NP_001397343.1  ATP-binding cassette sub-family C member 9 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC121611
  4. NM_001410415.1NP_001397344.1  ATP-binding cassette sub-family C member 9 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC121611
  5. NM_001410416.1NP_001397345.1  ATP-binding cassette sub-family C member 9 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC121611
  6. NM_011511.3NP_035641.1  ATP-binding cassette sub-family C member 9 isoform a

    See identical proteins and their annotated locations for NP_035641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR and coding region compared to variant 2. The resulting isoform (a, also known as SUR2B or SUR2-40) has a distinct C-terminus compared to isoform b.
    Source sequence(s)
    AC121611
    Consensus CDS
    CCDS39696.1
    UniProtKB/Swiss-Prot
    P70170
    Related
    ENSMUSP00000098390.3, ENSMUST00000100827.5
    Conserved Domains (1) summary
    TIGR00957
    Location:231543
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  7. NM_021041.3NP_066378.1  ATP-binding cassette sub-family C member 9 isoform b

    See identical proteins and their annotated locations for NP_066378.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes isoform b (also known as SUR2A or SUR2-39).
    Source sequence(s)
    AC121611
    Consensus CDS
    CCDS39699.1
    UniProtKB/Swiss-Prot
    O08902, O08920, P70170, P70171
    Related
    ENSMUSP00000084805.5, ENSMUST00000087527.11
    Conserved Domains (1) summary
    TIGR00957
    Location:231538
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  8. NM_021042.3NP_066379.2  ATP-binding cassette sub-family C member 9 isoform c

    See identical proteins and their annotated locations for NP_066379.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (c, also known as SUR2 delta14/39) has the same N- and C-termini but is shorter compared to isoform b.
    Source sequence(s)
    AC121611
    Consensus CDS
    CCDS39697.1
    UniProtKB/Swiss-Prot
    P70170
    Related
    ENSMUSP00000072914.6, ENSMUST00000073173.12
    Conserved Domains (4) summary
    TIGR00957
    Location:231503
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03288
    Location:12721511
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    cd03290
    Location:635851
    ABCC_SUR1_N; ATP-binding cassette domain of the sulfonylurea receptor, subfamily C
    cl00549
    Location:9601194
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    142533592..142648472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506949.5XP_006507012.1  ATP-binding cassette sub-family C member 9 isoform X1

    See identical proteins and their annotated locations for XP_006507012.1

    UniProtKB/Swiss-Prot
    P70170
    Conserved Domains (1) summary
    TIGR00957
    Location:231543
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  2. XM_006506950.5XP_006507013.1  ATP-binding cassette sub-family C member 9 isoform X1

    See identical proteins and their annotated locations for XP_006507013.1

    UniProtKB/Swiss-Prot
    P70170
    Conserved Domains (1) summary
    TIGR00957
    Location:231543
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  3. XM_006506951.5XP_006507014.1  ATP-binding cassette sub-family C member 9 isoform X1

    See identical proteins and their annotated locations for XP_006507014.1

    UniProtKB/Swiss-Prot
    P70170
    Conserved Domains (1) summary
    TIGR00957
    Location:231543
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  4. XM_036166002.1XP_036021895.1  ATP-binding cassette sub-family C member 9 isoform X2

    UniProtKB/Swiss-Prot
    O08902, O08920, P70170, P70171
    Conserved Domains (1) summary
    TIGR00957
    Location:231538
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_021043.1: Suppressed sequence

    Description
    NM_021043.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.