Syn1 synapsin I [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Syn1provided by RGD
Official Full Name: synapsin Iprovided by RGD
Primary source: RGD:3797
See related: Ensembl:ENSRNOG00000010365 AllianceGenome:RGD:3797
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium-dependent protein binding activity. Involved in neuron development and synapse organization. Located in several cellular components, including dendrite; presynaptic active zone; and synaptic vesicle. Is anchored component of synaptic vesicle membrane. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in X-linked epilepsy with variable learning disabilities and behavior disorders and non-syndromic X-linked intellectual disability 50. Orthologous to human SYN1 (synapsin I). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 151.4), Spleen (RPKM 21.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (3725745..3780940)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (1172208..1227400)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (1321315..1379202)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in Rats with Alzheimer's Disease: An Experimental and Bioinformatics Study.
Title: Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in Rats with Alzheimer's Disease: An Experimental and Bioinformatics Study.
The Phosphoprotein Synapsin Ia Regulates the Kinetics of Dense-Core Vesicle Release.
Title: The Phosphoprotein Synapsin Ia Regulates the Kinetics of Dense-Core Vesicle Release.
MicroRNA-153 impairs hippocampal synaptic vesicle trafficking via downregulation of synapsin I in rats following chronic cerebral hypoperfusion.
Title: MicroRNA-153 impairs hippocampal synaptic vesicle trafficking via downregulation of synapsin I in rats following chronic cerebral hypoperfusion.
The miR1345p/Foxp2/Syn1 axis was found to contribute to cognitive impairment in a chronic ischemiainduced early VD model, which may enable the development of new therapeutic strategies for the prevention and treatment of VD.
Title: miR‑134‑5p/Foxp2/Syn1 is involved in cognitive impairment in an early vascular dementia rat model.
Study shows that neonatal anesthesia impairs synapsin 1 and synaptotagmin 1, two key regulators of synaptic vesicle docking and fusion.
Title: Neonatal anesthesia impairs synapsin 1 and synaptotagmin 1, two key regulators of synaptic vesicle docking and fusion.
The synapsin 1 in the insular cortex as a part of pathophysiological process that determines predisposition of Krushinsky-Molodkina rats to audiogenic seizures.
Title: The expression and distribution of seizure-related and synaptic proteins in the insular cortex of rats genetically prone to audiogenic seizures.
SUMOylation of synapsin Ia (SynIa) at K687 is necessary for SynIa function. Replacement of endogenous SynIa with a non-SUMOylatable mutant decreases the size of the releasable vesicle pool and impairs stimulated SV exocytosis.
Title: SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation.
Report behavioral testing-related changes in the expression of synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats.
Title: Behavioral testing-related changes in the expression of Synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats.
Results suggest a mechanism of A2aR modulation of neurotransmitter release in cultured cells from medulla oblongata and suggest that protein kinase A mediates this modulation of neurotransmitter release via synapsin I phosphorylation
Title: Protein kinase A mediates adenosine A2a receptor modulation of neurotransmitter release via synapsin I phosphorylation in cultured cells from medulla oblongata.
rSynI(1.0)-minCMV drives robust and neuron-specific transgene expression throughout the CNS and is therefore useful for viral vector-mediated neuron-specific gene delivery and generation of neuron-specific transgenic animals.
Title: Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXRat60 (e-PCR), detects polymorphism
- UniSTS:228436

UniSTS:224356 (e-PCR)
- UniSTS:224356

DXWox10 (e-PCR)
- UniSTS:517822

GDB:305493 (e-PCR)
- UniSTS:156411

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in neuron development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter secretion	TAS Traceable Author Statement more info	PubMed
involved_in regulation of synaptic vesicle cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle clustering	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
is_active_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cell body	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in extrinsic component of synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptonemal complex	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	HDA more info	PubMed

General protein information

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Preferred Names: synapsin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110782.2 → NP_001104252.1 synapsin-1 isoform b

See identical proteins and their annotated locations for NP_001104252.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1, which results in a frame-shift, and a shorter isoform (b) with a distinct C-terminus compared to isoform a.

Source sequence(s)

BG378858, CO401107, FQ084192, JAXUCZ010000021, M27924

UniProtKB/TrEMBL

A6JZR0

Conserved Domains (3) summary

pfam02078
Location:115 → 212

Synapsin; Synapsin, N-terminal domain

pfam10581
Location:1 → 27

Synapsin_N; Synapsin N-terminal

cl17255
Location:214 → 416

ATP-grasp_4; ATP-grasp domain
NM_019133.2 → NP_062006.1 synapsin-1 isoform a

See identical proteins and their annotated locations for NP_062006.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

BG378858, CO401107, FQ084192, JAXUCZ010000021, M27812

UniProtKB/Swiss-Prot

P09951, Q9WUX7

UniProtKB/TrEMBL

A6JZQ9

Related

ENSRNOP00000014250.5, ENSRNOT00000014250.7

Conserved Domains (3) summary

pfam02078
Location:115 → 212

Synapsin; Synapsin, N-terminal domain

pfam10581
Location:1 → 27

Synapsin_N; Synapsin N-terminal

cl17255
Location:214 → 416

ATP-grasp_4; ATP-grasp domain