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    Zdhhc5 zinc finger DHHC-type palmitoyltransferase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362156, updated on 2-May-2024

    Summary

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    Official Symbol
    Zdhhc5provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 5provided by RGD
    Primary source
    RGD:1589737
    See related
    Ensembl:ENSRNOG00000006832 AllianceGenome:RGD:1589737
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DHHC-5
    Summary
    Predicted to enable palmitoyltransferase activity. Predicted to be involved in positive regulation of pattern recognition receptor signaling pathway; positive regulation of protein localization; and protein palmitoylation. Predicted to be located in dendrite and phagocytic vesicle. Predicted to be active in plasma membrane. Orthologous to human ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 196.5), Kidney (RPKM 193.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zdhhc5 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90178734..90206889, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69772037..69800142, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72090526..72118406, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene selenoprotein H Neighboring gene thioredoxin-related transmembrane protein 2 Neighboring gene mediator complex subunit 19 Neighboring gene uncharacterized LOC120101590 Neighboring gene cleavage factor polyribonucleotide kinase subunit 1 Neighboring gene yippee-like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway. Collura KM, et al. J Biol Chem, 2020 Nov 13. PMID 32958558, Free PMC Article
    2. Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5. Brigidi GS, et al. Nat Commun, 2015 Sep 3. PMID 26334723, Free PMC Article
    3. S-acylated Golga7b stabilises DHHC5 at the plasma membrane to regulate cell adhesion. Woodley KT, et al. EMBO Rep, 2019 Oct 4. PMID 31402609, Free PMC Article
    4. Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking. Thomas GM, et al. Neuron, 2012 Feb 9. PMID 22325201, Free PMC Article
    5. Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. Kokkola T, et al. FEBS Lett, 2011 Sep 2. PMID 21820437

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway.
      Title: The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway.
    2. DHHC5, to palmitoylate substrates in an activity-dependent manner is dependent on changes in its subcellular localization.
      Title: Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5.
    3. this study identified the first neuronal DHHC5/8 substrate, define novel mechanisms controlling palmitoylation specificity, and suggest further links between dysregulated palmitoylation and neuropathological conditions.
      Title: Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic specialization, intracellular component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic specialization, intracellular component IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC5
    Names
    membrane-associated DHHC5 zinc finger protein
    probable palmitoyltransferase ZDHHC5
    zinc finger DHHC domain-containing protein 5
    zinc finger, DHHC domain containing 5
    zinc finger, DHHC-type containing 5
    NP_001034427.1
    XP_017447385.1
    XP_017447386.1
    XP_017447387.1
    XP_038961338.1
    XP_063140208.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039338.1 → NP_001034427.1  palmitoyltransferase ZDHHC5

      See identical proteins and their annotated locations for NP_001034427.1

      Status: PROVISIONAL

      Source sequence(s)
      AY871203
      UniProtKB/Swiss-Prot
      Q2THW7
      UniProtKB/TrEMBL
      A6HMR0
      Conserved Domains (1) summary
      pfam01529
      Location:99 → 224
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      90178734..90206889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591896.3 → XP_017447385.1  palmitoyltransferase ZDHHC5 isoform X1

      UniProtKB/Swiss-Prot
      Q2THW7
      UniProtKB/TrEMBL
      A6HMR0
      Related
      ENSRNOP00000009708.4
      Conserved Domains (1) summary
      pfam01529
      Location:99 → 224
      zf-DHHC; DHHC palmitoyltransferase

    2. XM_017591898.3 → XP_017447387.1  palmitoyltransferase ZDHHC5 isoform X1

      UniProtKB/Swiss-Prot
      Q2THW7
      UniProtKB/TrEMBL
      A6HMR0
      Conserved Domains (1) summary
      pfam01529
      Location:99 → 224
      zf-DHHC; DHHC palmitoyltransferase

    3. XM_017591897.3 → XP_017447386.1  palmitoyltransferase ZDHHC5 isoform X1

      UniProtKB/Swiss-Prot
      Q2THW7
      UniProtKB/TrEMBL
      A6HMR0
      Conserved Domains (1) summary
      pfam01529
      Location:99 → 224
      zf-DHHC; DHHC palmitoyltransferase

    4. XM_039105410.2 → XP_038961338.1  palmitoyltransferase ZDHHC5 isoform X2

      UniProtKB/TrEMBL
      A6HMR0
      Conserved Domains (1) summary
      pfam01529
      Location:46 → 171
      DHHC; DHHC palmitoyltransferase

    5. XM_063284138.1 → XP_063140208.1  palmitoyltransferase ZDHHC5 isoform X1

      UniProtKB/Swiss-Prot
      Q2THW7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2THW7.1 GenPept UniProtKB/Swiss-Prot:Q2THW7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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