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ZDHHC5 zinc finger DHHC-type palmitoyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 25921, updated on 3-Oct-2020

Summary

Official Symbol
ZDHHC5provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:18472
See related
Ensembl:ENSG00000156599 MIM:614586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHHC5; ZNF375
Expression
Ubiquitous expression in esophagus (RPKM 30.1), thyroid (RPKM 23.7) and 25 other tissues See more
Orthologs

Genomic context

See ZDHHC5 in Genome Data Viewer
Location:
11q12.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (57668040..57701187)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57435223..57468659)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene yippee like 4 Neighboring gene cleavage factor polyribonucleotide kinase subunit 1 Neighboring gene TMX2-CTNND1 readthrough (NMD candidate) Neighboring gene mediator complex subunit 19 Neighboring gene peptidylprolyl isomerase A pseudogene 42 Neighboring gene thioredoxin related transmembrane protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1748, DKFZp586K0524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
dendrite IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
palmitoyltransferase ZDHHC5
Names
DHHC-5
membrane-associated DHHC5 zinc finger protein
probable palmitoyltransferase ZDHHC5
zinc finger DHHC domain-containing protein 5
zinc finger DHHC-type containing 5
zinc finger protein 375
zinc finger, DHHC domain containing 5
NP_056272.2
XP_011543201.1
XP_011543202.1
XP_011543203.1
XP_016872987.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015457.3NP_056272.2  palmitoyltransferase ZDHHC5

    See identical proteins and their annotated locations for NP_056272.2

    Status: VALIDATED

    Source sequence(s)
    AB051535, AK023130, AL117662
    Consensus CDS
    CCDS7965.1
    UniProtKB/Swiss-Prot
    Q9C0B5
    UniProtKB/TrEMBL
    A0A024R546
    Related
    ENSP00000287169.3, ENST00000287169.8
    Conserved Domains (2) summary
    pfam01529
    Location:99224
    DHHC; DHHC palmitoyltransferase
    pfam15710
    Location:594704
    DUF4671; Domain of unknown function (DUF4671)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    57668040..57701187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017498.2XP_016872987.1  palmitoyltransferase ZDHHC5 isoform X2

  2. XM_011544900.1XP_011543202.1  palmitoyltransferase ZDHHC5 isoform X1

    See identical proteins and their annotated locations for XP_011543202.1

    UniProtKB/Swiss-Prot
    Q9C0B5
    UniProtKB/TrEMBL
    A0A024R546
    Conserved Domains (2) summary
    pfam01529
    Location:99224
    DHHC; DHHC palmitoyltransferase
    pfam15710
    Location:594704
    DUF4671; Domain of unknown function (DUF4671)
  3. XM_011544899.1XP_011543201.1  palmitoyltransferase ZDHHC5 isoform X1

    See identical proteins and their annotated locations for XP_011543201.1

    UniProtKB/Swiss-Prot
    Q9C0B5
    UniProtKB/TrEMBL
    A0A024R546
    Conserved Domains (2) summary
    pfam01529
    Location:99224
    DHHC; DHHC palmitoyltransferase
    pfam15710
    Location:594704
    DUF4671; Domain of unknown function (DUF4671)
  4. XM_011544901.1XP_011543203.1  palmitoyltransferase ZDHHC5 isoform X1

    See identical proteins and their annotated locations for XP_011543203.1

    UniProtKB/Swiss-Prot
    Q9C0B5
    UniProtKB/TrEMBL
    A0A024R546
    Conserved Domains (2) summary
    pfam01529
    Location:99224
    DHHC; DHHC palmitoyltransferase
    pfam15710
    Location:594704
    DUF4671; Domain of unknown function (DUF4671)

RNA

  1. XR_001747825.2 RNA Sequence

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