Slco1c1 solute carrier organic anion transporter family, member 1c1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slco1c1provided by RGD
Official Full Name: solute carrier organic anion transporter family, member 1c1provided by RGD
Primary source: RGD:628660
See related: Ensembl:ENSRNOG00000009740 AllianceGenome:RGD:628660
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BAST1; Bsat1; Oatp14; OATP-14; OATP1C1; Slc21a14
Summary: Enables bile acid transmembrane transporter activity. Involved in bile acid and bile salt transport. Located in basolateral plasma membrane. Biomarker of primary biliary cholangitis. Orthologous to human SLCO1C1 (solute carrier organic anion transporter family member 1C1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 167.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q44

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (176197736..176244401)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (174466621..174513290)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (175729709..175776749)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRISRP/Cas9-mediated knockout of Mct8 reveals a functional involvement of Mct8 in testis and sperm development in a rat.
Title: CRISRP/Cas9-mediated knockout of Mct8 reveals a functional involvement of Mct8 in testis and sperm development in a rat.
Differential expression and immunoreactivity of thyroid hormone transporters MCT8 and OATP1C1 in rat ovary.
Title: Differential expression and immunoreactivity of thyroid hormone transporters MCT8 and OATP1C1 in rat ovary.
Prenatal exposure to monoclonal antibody brain-specific anion transporter-1 blocks brain-specific anion transporter-1 and limits T4 influx to the brain. This impairs the cognitive function in exposed progeny in the post-natal life.
Title: Prenatal exposure to brain-specific anion transporter-1-specific monoclonal antibodies impairs cognitive function in post-natal life.
This study demonstrated that reduction of the Mct8 mRNA expression in hippocampus of thyroidectomized Wistar rats.
Title: Antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism.
The coordinated effects of Oatp1c1, Mct8, D2 and D3 in the placental barrier may regulate both transplacental TH passage and the development of trophoblast cells during thyroid dysfunction throughout the pregnancy.
Title: Expression of organic anion transporting polypeptide 1c1 and monocarboxylate transporter 8 in the rat placental barrier and the compensatory response to thyroid dysfunction.
The data demonstrate that OATP1c1 and MCT8 expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents.
Title: Parallel regulation of thyroid hormone transporters OATP1c1 and MCT8 during and after endotoxemia at the blood-brain barrier of male rodents.
In the brain, BSAT1 is localized predominantly in astrocytes, but not in endothelial cells.
Title: Organ, cellular, and subcellular localization of brain-specific anion transporter BSAT1.
Antibody blocking of BSAT1 during the prenatal period is followed by cognitive impairments, which are probably related to thyroxin deficiency in the nervous tissue.
Title: Effects of prenatal exposure to antibodies against brain-specific anion transporter on cognitive functions in rats.
Oatp1c1-dependent substrate transport is a complex process involving substrate interaction with multiple binding sites and competition binding of other substrates.
Title: The blood-brain barrier thyroxine transporter organic anion-transporting polypeptide 1c1 displays atypical transport kinetics.
OATP14 mRNA and protein are strongly enriched in rat cerebral microvessels but not in human microvessels.
Title: Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU046632 (e-PCR)
- UniSTS:111269

D4Got111 (e-PCR)
- UniSTS:113324

Slco1c1 (e-PCR), detects polymorphism
- UniSTS:546035

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyroid hormone transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables thyroid hormone transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid and bile salt transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in organic anion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of thyroid hormone generation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of thyroid hormone generation	ISO Inferred from Sequence Orthology more info
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in thyroid hormone transport	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 1C1

Names: BBB-specific anion transporter type 1; blood-brain barrier specific anion transporter; blood-brain barrier-specific anion transporter 1; organic anion transporter 1C1; organic anion-transporting polypeptide 14; solute carrier family 21 (organic anion transporter), member 14; solute carrier family 21 member 14; thyroxine transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053441.1 → NP_445893.1 solute carrier organic anion transporter family member 1C1

See identical proteins and their annotated locations for NP_445893.1

Status: PROVISIONAL

Source sequence(s)

AF306546

UniProtKB/Swiss-Prot

Q9EPZ7

UniProtKB/TrEMBL

A0A8I6GJ93

Related

ENSRNOP00000013230.3, ENSRNOT00000013230.6

Conserved Domains (3) summary

cd06174
Location:46 → 459

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:476 → 529

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

pfam03137
Location:44 → 642

OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

176197736..176244401

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108471.2 → XP_038964399.1 solute carrier organic anion transporter family member 1C1 isoform X1

UniProtKB/TrEMBL

A0A8I6GJ93, A6IMP0, G3V795

Conserved Domains (1) summary

cl28910
Location:42 → 583

MFS; Major Facilitator Superfamily