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    impa1 inositol monophosphatase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 437018, updated on 27-Mar-2024

    Summary

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    Official Symbol
    impa1provided by ZNC
    Official Full Name
    inositol monophosphatase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-245
    See related
    Ensembl:ENSDARG00000003517 AllianceGenome:ZFIN:ZDB-GENE-040718-245
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:100926
    Summary
    Predicted to enable inositol monophosphate 1-phosphatase activity. Predicted to be involved in inositol metabolic process; inositol phosphate dephosphorylation; and signal transduction. Predicted to act upstream of or within phosphatidylinositol phosphate biosynthetic process. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability. Orthologous to human IMPA1 (inositol monophosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See impa1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (26682927..26688922)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (27027294..27033451)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:dkey-181m9.8 Neighboring gene tocopherol (alpha) transfer protein Neighboring gene aspartate beta-hydroxylase Neighboring gene cadherin 7a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Salinity-induced regulation of the myo-inositol biosynthesis pathway in tilapia gill epithelium. Sacchi R, et al. J Exp Biol, 2013 Dec 15. PMID 24072791, Free PMC Article
    2. Functional enrichment analysis based on long noncoding RNA associations. Hung KS, et al. BMC Syst Biol, 2018 Apr 24. PMID 29745842, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol monophosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol monophosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol monophosphate 3-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol monophosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol monophosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inositol monophosphatase 1
    Names
    inositol(myo)-1(or 4)-monophosphatase 1
    NP_001002745.1
    XP_005163453.1
    XP_021335575.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002745.1 → NP_001002745.1  inositol monophosphatase 1

      See identical proteins and their annotated locations for NP_001002745.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076438
      UniProtKB/TrEMBL
      A0A8M1N1A6, Q6DGB2
      Related
      ENSDARP00000018348.4, ENSDART00000010683.6
      Conserved Domains (1) summary
      cd01639
      Location:9 → 254
      IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      26682927..26688922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163396.4 → XP_005163453.1  inositol monophosphatase 1 isoform X1

      See identical proteins and their annotated locations for XP_005163453.1

      UniProtKB/TrEMBL
      A0A8M1N1A6, Q6DGB2
      Related
      ENSDARP00000112912.1, ENSDART00000131411.2
      Conserved Domains (1) summary
      cd01639
      Location:9 → 254
      IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...

    2. XM_021479900.1 → XP_021335575.1  inositol monophosphatase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M1N1A6, Q6DGB2
      Conserved Domains (1) summary
      cd01639
      Location:9 → 254
      IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...
    Nucleotide Protein Strain
    Heading Accession and Version

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