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Impa1 inositol (myo)-1(or 4)-monophosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 55980, updated on 8-Jan-2023

Summary

Official Symbol
Impa1provided by MGI
Official Full Name
inositol (myo)-1(or 4)-monophosphatase 1provided by MGI
Primary source
MGI:MGI:1933158
See related
Ensembl:ENSMUSG00000027531 AllianceGenome:MGI:1933158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610002K09Rik; 2900059K10Rik
Summary
Enables magnesium ion binding activity. Predicted to be involved in phosphatidylinositol biosynthetic process; polyol metabolic process; and signal transduction. Predicted to be located in axon; cytoplasm; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability. Orthologous to human IMPA1 (inositol monophosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 9.6), cerebellum adult (RPKM 9.5) and 28 other tissues See more
Orthologs
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Genomic context

See Impa1 in Genome Data Viewer
Location:
3; 3 A1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (10377016..10396499, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (10311956..10331439, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene fatty acid binding protein 4, adipocyte Neighboring gene fatty acid binding protein 12 Neighboring gene predicted gene, 37316 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 5 Neighboring gene zinc finger, AN1-type domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables inositol monophosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inositol monophosphate 1-phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables inositol monophosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol monophosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol monophosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables lithium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in inositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within inositol metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in inositol phosphate dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inositol phosphate dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphate-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inositol monophosphatase 1
Names
D-galactose 1-phosphate phosphatase
IMP 1
IMPase 1
inositol-1(or 4)-monophosphatase 1
lithium-sensitive myo-inositol monophosphatase A1
myo-inositol monophosphatase 1
NP_001297362.1
NP_061352.2
XP_006530140.1
XP_006530141.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310433.1NP_001297362.1  inositol monophosphatase 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK145472, AK152774, BY283562
    Consensus CDS
    CCDS79884.1
    UniProtKB/TrEMBL
    A0A0A6YW07, Q924B0
    Related
    ENSMUSP00000141345.2, ENSMUST00000191670.6
    Conserved Domains (1) summary
    cd01639
    Location:8164
    IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...
  2. NM_018864.6NP_061352.2  inositol monophosphatase 1 isoform 1

    See identical proteins and their annotated locations for NP_061352.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK145472, AK152774, BY283562
    Consensus CDS
    CCDS17240.1
    UniProtKB/TrEMBL
    Q924B0
    Related
    ENSMUSP00000068174.9, ENSMUST00000065938.15
    Conserved Domains (1) summary
    cd01639
    Location:8254
    IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    10377016..10396499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530077.4XP_006530140.1  inositol monophosphatase 1 isoform X1

    Conserved Domains (1) summary
    cd01639
    Location:61307
    IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...
  2. XM_006530078.5XP_006530141.1  inositol monophosphatase 1 isoform X2

    Conserved Domains (1) summary
    cd01639
    Location:61217
    IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...