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    UBP5 putative ubiquitin-specific protease UBP5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856887, updated on 11-Apr-2024

    Summary

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    Gene symbol
    UBP5
    Gene description
    putative ubiquitin-specific protease UBP5
    Primary source
    SGD:S000000946
    Locus tag
    YER144C
    See related
    AllianceGenome:SGD:S000000946
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Located in cellular bud neck. Part of incipient cellular bud site. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to several human genes including USP32 (ubiquitin specific peptidase 32); USP50 (ubiquitin specific peptidase 50); and USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (457806..460223, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene DNA-3-methyladenine glycosylase II Neighboring gene Ddi1p Neighboring gene high-affinity iron permease FTR1 Neighboring gene uncharacterized protein Neighboring gene RNA-binding protein LSM5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UBP5 encodes a putative yeast ubiquitin-specific protease that is related to the human Tre-2 oncogene product. Xiao W, et al. Yeast, 1994 Nov. PMID 7871889
    2. A conserved late endosome-targeting signal required for Doa4 deubiquitylating enzyme function. Amerik A, et al. J Cell Biol, 2006 Dec 4. PMID 17145966, Free PMC Article
    3. Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome. Papa FR, et al. Mol Biol Cell, 1999 Mar. PMID 10069815, Free PMC Article
    4. The N-terminal domains determine cellular localization and functions of the Doa4 and Ubp5 deubiquitinating enzymes. Wolters N, et al. Biochem Biophys Res Commun, 2015 Nov 20. PMID 26427873
    5. Cdc50p, a conserved endosomal membrane protein, controls polarized growth in Saccharomyces cerevisiae. Misu K, et al. Mol Biol Cell, 2003 Feb. PMID 12589066, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. corresponding region of homologous Ubp5 is critical for its bud neck localization in dividing cells. Conceivably, Ubp5 plays an essential role in cytokinesis
      Title: The N-terminal domains determine cellular localization and functions of the Doa4 and Ubp5 deubiquitinating enzymes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative ubiquitin-specific protease UBP5
    NP_011071.3
    • Putative ubiquitin-specific protease; concentrates at the bud neck; UBP5 has a paralog, DOA4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      457806..460223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179034.3 → NP_011071.3  TPA: putative ubiquitin-specific protease UBP5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011071.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM51, P39944
      UniProtKB/TrEMBL
      A0A8H8UM07, C8Z7G4, N1P3M4
      Conserved Domains (2) summary
      smart00450
      Location:159 → 280
      RHOD; Rhodanese Homology Domain
      COG5533
      Location:359 → 805
      COG5533; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39944.1

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