3D1P,1H4K,3HZU,1H4K


Conserved Protein Domain Family
RHOD
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smart00450: RHOD 
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Rhodanese Homology Domain
An alpha beta fold found duplicated in the Rhodanese protein. The the Cysteine containing enzymatically active version of the domain is also found in the CDC25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and stress proteins such as Senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions with a loss of the cysteine are also seen in Dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases. These are likely to play a role in protein interactions.
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Statistics
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PSSM-Id: 197731
Aligned: 143 rows
Threshold Bit Score: 31.2758
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3D1P_A      37 HDPNVVLVDVRE--PSEYSIVHIPASIN----VPYRSHPDafaldpl--------------------------------- 77   baker's yeast
CAA30397    17 QEKEAVLVDIRD--PQSFAMGHAVQAFH----LTNDTLGAf--------------------------------------- 51   Escherichia coli
Q93534     318 GSVNFFIVDTRS--NTDFDSGHFVSSFN----LDCVAIVDepekfeia-------------------------------- 359  Caenorhabditis e...
Q94606    1578 FDSGVYLVDVREqpTENALRDSVLGAIS----VPLYTAALqpregsdmrpsavtdevgdvdsdaagagwgiveqqermqe 1653 Leishmania major...
EGI94599    24 NKEDAVVVDLRQ--RDDFRKGHIAGSIN----Llpseik----------------------------------------- 56   Shigella boydii ...
NP_501053   25 HERNVIVLDCRS------NGDSVKRANRffcsLRLPALLQrrlmggsmrls----------------------------- 69   nematode
EDZ72589   111 PDEKVLLLDVRP--FTEHAKSIITNSIH----VCLPSTLLrrknftfsklld---------------------------- 156  Saccharomyces ce...
EDN61345   328 EREKVLLIDLRI--PQRSAINHIVAPNL----VNVDPNLLwdkqtntpiykd---------------------------- 373  Saccharomyces ce...
CAA42167    21 TESVSWIIDLRL--HSKYAVSHIKNAIN----VSLPTALLrrpsfdigk------------------------------- 63   fission yeast
YP_248370   16 Q-QGAILVDIRD--NMRFAYSHPKGAFH----LTNQSFLQf--------------------------------------- 49   Haemophilus infl...

3D1P_A      78 ----------------------------------------------------------efekqigIPKPDSAKELIFYC- 98   baker's yeast
CAA30397    52 -----------------------------------------------------------------MRDNDFDTPVMVMC- 65   Escherichia coli
Q93534     360 ---------------------------------------------------------lnslecykTSRRDEDHYLILGYg 382  Caenorhabditis e...
Q94606    1654 qqraeqdaaarqvedaaaaivrhvgnpamaaitprvwraaknhaapplpppqpsliscpwpvhpiVLKASRAPHVVLLT- 1732 Leishmania major...
EGI94599    57 ------------------------------------------------------------annvgELEKHKDKPVIVVD- 75   Shigella boydii ...
NP_501053   70 -------------------------------------------------------tvpdlkdlnnSPDQCPEVLLIPGDs 94   nematode
EDZ72589   157 ------------------------------------------------------nltpseqsvlkSKLAIDNLRIIIYD- 181  Saccharomyces ce...
EDN61345   374 -----------------------------------------------------dilehllkenenFINRNKFDYIVYYT- 399  Saccharomyces ce...
CAA42167    64 --------------------------------------------------------vfacikcnvKVSLDEINAIFLYDs 87   fission yeast
YP_248370   50 -----------------------------------------------------------------EELADFDSPIIVSC- 63   Haemophilus infl...

3D1P_A      99 --ASGKRG------------GEAQKVASSHGYSn----------TSLYPGSXNDWVSHGGD 135  baker's yeast
CAA30397    66 --YHGNSS------------KGAAQYLLQQGYDv----------VYSIDGGFEAWQRQFPA 102  Escherichia coli
Q93534     383 sdEEDNYM------------NMLIAMFIQKGKLh----------VSFVQGGYKKLHDCIGQ 421  Caenorhabditis elegans
Q94606    1733 --SGVVDAhel------plaHQLGVKLNACGVHn----------VSILRGGVASVRRALPE 1775 Leishmania major strain Friedlin
EGI94599    76 --GSGMQC------------QEPANALTKAGFAq----------VFVLKEGVAGWAGENLP 112  Shigella boydii 3594-74
NP_501053   95 --EQDEQLs-----------AALARNLKSNHYRhfvl----gepVKTLLSQFPTLRDAADE 138  nematode
EDZ72589   182 --STANQTessvslpcygiaSKLIEFDTNVKKT-----------VSILMCGFPQFKILFPD 229  Saccharomyces cerevisiae AWRI1631
EDN61345   400 --DVKTFMt-----------INFDYAFIFFYLMltsqktplttvPTTLLGGYEKWKKTLHS 447  Saccharomyces cerevisiae YJM789
CAA42167    88 -sMAGMNRi-----------YDLVQKFRRGGYSk---------kIYLLSNGFEAFASSHPD 127  fission yeast
YP_248370   64 --YHGVSS------------RNVATFLVEQGYKn----------VFSMIGGFDGWCRAELP 100  Haemophilus influenzae 86-028NP
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