Mbl1 mannose binding lectin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mbl1provided by RGD
Official Full Name: mannose binding lectin 1provided by RGD
Primary source: RGD:3055
See related: Ensembl:ENSRNOG00000011706 AllianceGenome:RGD:3055
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mbpa; Mlb1
Summary: Enables several functions, including calcium-dependent carbohydrate binding activity; mannose binding activity; and phosphatidylinositol-4-phosphate binding activity. Involved in complement activation, lectin pathway and protein homotrimerization. Located in extracellular space. Orthologous to human MBL1P (mannose binding lectin 1, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1232.3) See more
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Genomic context

Location:: 16p14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (17063232..17069271)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (17029146..17035187)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (18736154..18742193)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our data show an important role for MBL in the pathogenesis of brain ischemic injury and provide a strong support to the concept that MBL inhibition may be a relevant therapeutic target.
Title: Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia.
The expression of MBL was positively correlated with NF-kappaB expression in diabetic nephropathy.
Title: [Relationship between activation of mannan-binding lectin complement and NF-kappaB in diabetic nephropathy].
MASP-1 probably enhances complement activation triggered by MBP.MASP-2 complexes, but it cannot initiate activation itself
Title: Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases.
that the triple helical structure of the collagen-like domain is largely intact in the mutant proteins, but it is more easily unfolded than in wild-type MBP
Title: Localization of the serine protease-binding sites in the collagen-like domain of mannose-binding protein: indirect effects of naturally occurring mutations on protease binding and activation.

Submit: New GeneRIF Correction

General gene information

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Markers

RH94874 (e-PCR)
- UniSTS:120120

D16Wox9 (e-PCR)
- UniSTS:239726

d6mit11 (e-PCR)
- UniSTS:120477

BI289113 (e-PCR)
- UniSTS:246700

D16Arb5 (e-PCR), detects polymorphism
- UniSTS:226754

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mannose binding	IDA Inferred from Direct Assay more info	PubMed
enables oligosaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables polysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in complement activation, lectin pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within complement activation, lectin pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within killing by host of symbiont cells	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	IDA Inferred from Direct Assay more info	PubMed
involved_in surfactant homeostasis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mannose-binding protein A

Names: MBP-A; Mannose binding protein A, serum; mannan-binding protein; mannose binding lectin (A); mannose binding lectin 1, protein A; mannose binding lectin 2, protein C; mannose-binding lectin (protein A) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012599.2 → NP_036731.2 mannose-binding protein A precursor

See identical proteins and their annotated locations for NP_036731.2

Status: PROVISIONAL

Source sequence(s)

BC088159

UniProtKB/Swiss-Prot

P19999

UniProtKB/TrEMBL

A6K9L8

Related

ENSRNOP00000015723.2, ENSRNOT00000015723.7

Conserved Domains (2) summary

cd03591
Location:126 → 236

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:36 → 86

Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

17063232..17069271

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094193.2 → XP_038950121.1 mannose-binding protein A isoform X1

UniProtKB/TrEMBL

A6K9L9

Conserved Domains (1) summary

cd03591
Location:29 → 139

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)