Ube2i ubiquitin-conjugating enzyme E2I [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ube2iprovided by RGD
Official Full Name: ubiquitin-conjugating enzyme E2Iprovided by RGD
Primary source: RGD:3926
See related: Ensembl:ENSRNOG00000066579 AllianceGenome:RGD:3926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ubc9; UbcE2A
Summary: Enables bHLH transcription factor binding activity; protein C-terminus binding activity; and ubiquitin-like protein transferase activity. Involved in cellular protein metabolic process; positive regulation of DNA-binding transcription factor activity; and regulation of signal transduction. Located in dendrite; nucleus; and synapse. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 383.0), Spleen (RPKM 264.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (14782245..14802911, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (14277749..14294681, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (14618615..14639274, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UBC9 regulates Nav1.5 expression levels in a SUMOylation-independent manner.
Title: UBC9 regulates cardiac sodium channel Na(v)1.5 ubiquitination, degradation and sodium current density.
ISH analysis revealed expression of Ubc9 was high in neuronal stem cells and moderate in differentiated neurons at embryonic stages but in adult brain, moderate expression was observed in dentate granular neurons and pyramidal neurons
Title: Developmental regulation of Ubc9 in the rat nervous system.
Immunohistochemistry showed that Ubc9 and PIAS1 are markedly expressed in rat adrenal glomerulosa cells
Title: Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription.
Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9
Title: Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE107288 (e-PCR)
- UniSTS:261482

RH127604 (e-PCR)
- UniSTS:210914

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables HLH domain binding	ISO Inferred from Sequence Orthology more info
enables RING-like zinc finger domain binding	ISO Inferred from Sequence Orthology more info
enables SUMO conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO conjugating enzyme activity	ISO Inferred from Sequence Orthology more info
enables SUMO transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables SUMO transferase activity	ISO Inferred from Sequence Orthology more info
enables bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small protein activating enzyme binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nuclear export	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular steroid hormone receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
part_of SUMO ligase complex	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in fibrillar center	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info
part_of transferase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SUMO-conjugating enzyme UBC9

Names: RING-type E3 SUMO transferase UBC9; SUMO-protein ligase; Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9); ubiquitin carrier protein 9; ubiquitin carrier protein I; ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-conjugating enzyme UbcE2A; ubiquitin-protein ligase I

NP_037182.1

EC 6.3.2.19

XP_006245981.1

EC 6.3.2.19

XP_006245982.1

EC 6.3.2.19

XP_008765771.3

EC 6.3.2.19

XP_017452533.1

EC 6.3.2.19

XP_063124544.1

EC 6.3.2.19

XP_063124546.1

EC 6.3.2.19

XP_063124547.1

EC 6.3.2.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428972.1 → NP_001415901.1 SUMO-conjugating enzyme UBC9 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_001428973.1 → NP_001415902.1 SUMO-conjugating enzyme UBC9 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_001428974.1 → NP_001415903.1 SUMO-conjugating enzyme UBC9 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_001428975.1 → NP_001415904.1 SUMO-conjugating enzyme UBC9 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_001428976.1 → NP_001415905.1 SUMO-conjugating enzyme UBC9 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_013050.3 → NP_037182.1 SUMO-conjugating enzyme UBC9 isoform 1

See identical proteins and their annotated locations for NP_037182.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P63281

UniProtKB/TrEMBL

A6HD16

Related

ENSRNOP00000085922.1, ENSRNOT00000104064.1

Conserved Domains (1) summary

pfam00179
Location:8 → 152

UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

14782245..14802911 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268476.1 → XP_063124546.1 SUMO-conjugating enzyme UBC9 isoform X3
XM_063268474.1 → XP_063124544.1 SUMO-conjugating enzyme UBC9 isoform X2
XM_008767549.4 → XP_008765771.3 SUMO-conjugating enzyme UBC9 isoform X1

UniProtKB/TrEMBL

A0A0G2KB55
XM_006245920.5 → XP_006245982.1 SUMO-conjugating enzyme UBC9 isoform X4

UniProtKB/Swiss-Prot

P63281

UniProtKB/TrEMBL

A6HD16

Conserved Domains (1) summary

pfam00179
Location:8 → 152

UQ_con; Ubiquitin-conjugating enzyme
XM_017597044.3 → XP_017452533.1 SUMO-conjugating enzyme UBC9 isoform X4

UniProtKB/Swiss-Prot

P63281

UniProtKB/TrEMBL

A6HD16

Conserved Domains (1) summary

pfam00179
Location:8 → 152

UQ_con; Ubiquitin-conjugating enzyme
XM_063268477.1 → XP_063124547.1 SUMO-conjugating enzyme UBC9 isoform X5
XM_006245919.5 → XP_006245981.1 SUMO-conjugating enzyme UBC9 isoform X4

UniProtKB/Swiss-Prot

P63281

UniProtKB/TrEMBL

A6HD16

Conserved Domains (1) summary

pfam00179
Location:8 → 152

UQ_con; Ubiquitin-conjugating enzyme