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UBE2I ubiquitin conjugating enzyme E2 I [ Homo sapiens (human) ]

Gene ID: 7329, updated on 6-Jan-2019

Summary

Official Symbol
UBE2Iprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Iprovided by HGNC
Primary source
HGNC:HGNC:12485
See related
Ensembl:ENSG00000103275 MIM:601661
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P18; UBC9; C358B7.1
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 23.2), endometrium (RPKM 17.8) and 25 other tissues See more
Orthologs

Genomic context

See UBE2I in Genome Data Viewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (1309153..1327018)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1357420..1377019)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene tryptase pseudogene 1 Neighboring gene tryptase pseudogene 2 Neighboring gene ribosomal protein S20 pseudogene 2 Neighboring gene BAI1 associated protein 3 Neighboring gene TSR3, acp transferase ribosome maturation factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Levels of HIV-1 gp120 and Endo Hf-resistant gp120 are reduced in the absence of UBC9 expression. Degradation of gp120 occurs before transport to the plasma membrane and the lipid rafts in the UBC9 knockdown cells PubMed
env UBC9 contributes to viral glycoproteins gp120/gp41 stability in the presence of Gag expression and affects incorporation of the gp120/gp41 into virions PubMed
Envelope transmembrane glycoprotein gp41 env UBC9 contributes to viral glycoproteins gp120/gp41 stability in the presence of Gag expression and affects incorporation of the gp120/gp41 into released virions PubMed
Pr55(Gag) gag HIV-1 Gag trafficking and association with the plasma membrane is altered in the absebce of UBC9 PubMed
gag UBC9 contributes to viral glycoproteins gp120/gp41 stability in the presence of Gag expression and affects incorporation of the gp120/gp41 into released virions PubMed
gag Disrupting the function of KIF4 leads Gag transient accumulation in discrete, perinuclear, nonendocytic clusters that co-localize with endogenous KIF4, Ubc9, and SUMO PubMed
gag Coimmunoprecipitation shows that HIV-1 Gag and human UBC9 interact in vivo. HIV-1 Gag and human UBC9 colocalize in HIV-1-expressing cells PubMed
integrase gag-pol HIV-1 IN interacts with SUMO1/SUMO2 and Ubc9 in cells. Upregulations of SUMO1/SUMO2 and Ubc9 inhibit HIV-1 integration, while downregulations of SUMO1/SUMO2 and Ubc9 increase HIV-1 integration PubMed
p6 gag HIV-1 p6 interacts with Ubc9 in a yeast two-hybrid system PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
HLH domain binding IEA
Inferred from Electronic Annotation
more info
 
RING-like zinc finger domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA binding HDA PubMed 
SUMO conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SUMO conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
SUMO transferase activity EXP
Inferred from Experiment
more info
PubMed 
SUMO transferase activity TAS
Traceable Author Statement
more info
 
bHLH transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
small protein activating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of SUMO transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intracellular steroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
protein sumoylation TAS
Traceable Author Statement
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
fibrillar center IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
sumoylated E2 ligase complex IC
Inferred by Curator
more info
PubMed 
sumoylated E2 ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 
synaptonemal complex TAS
Traceable Author Statement
more info
PubMed 
transferase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SUMO-conjugating enzyme UBC9
Names
RING-type E3 SUMO transferase UBC9
SUMO-1-protein ligase
SUMO-protein ligase
ubiquitin carrier protein 9
ubiquitin carrier protein I
ubiquitin conjugating enzyme 9
ubiquitin conjugating enzyme E2I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)
ubiquitin-conjugating enzyme UbcE2A
ubiquitin-like protein SUMO-1 conjugating enzyme
ubiquitin-protein ligase E2I
ubiquitin-protein ligase I
NP_003336.1
NP_919235.1
NP_919236.1
NP_919237.1
XP_005255597.1
XP_005255598.1
XP_011520946.1
XP_011520947.1
XP_016879129.1
XP_024306200.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003345.5NP_003336.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_003336.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK291118, AL031714, BC000427, BI793063
    Consensus CDS
    CCDS10433.1
    UniProtKB/Swiss-Prot
    P63279
    UniProtKB/TrEMBL
    A8K503
    Related
    ENSP00000380649.3, ENST00000397514.7
    Conserved Domains (1) summary
    pfam00179
    Location:8152
    UQ_con; Ubiquitin-conjugating enzyme
  2. NM_194259.2NP_919235.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_919235.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AK291118, AL031714, BF315618, BG530957, BI793063, D45050
    Consensus CDS
    CCDS10433.1
    UniProtKB/Swiss-Prot
    P63279
    UniProtKB/TrEMBL
    A8K503
    Related
    ENSP00000380650.2, ENST00000397515.6
    Conserved Domains (1) summary
    pfam00179
    Location:8152
    UQ_con; Ubiquitin-conjugating enzyme
  3. NM_194260.2NP_919236.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_919236.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC120498, AL031714, BI793063, CX788607
    Consensus CDS
    CCDS10433.1
    UniProtKB/Swiss-Prot
    P63279
    Related
    ENSP00000348056.4, ENST00000355803.8
    Conserved Domains (1) summary
    pfam00179
    Location:8152
    UQ_con; Ubiquitin-conjugating enzyme
  4. NM_194261.2NP_919237.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_919237.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AB208988, AC120498, AL031714, BI793063
    Consensus CDS
    CCDS10433.1
    UniProtKB/Swiss-Prot
    P63279
    Related
    ENSP00000324897.5, ENST00000325437.9
    Conserved Domains (1) summary
    pfam00179
    Location:8152
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    1309153..1327018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522645.1XP_011520947.1  SUMO-conjugating enzyme UBC9 isoform X1

    See identical proteins and their annotated locations for XP_011520947.1

    UniProtKB/TrEMBL
    B0QYN7
    Conserved Domains (2) summary
    COG5078
    Location:1137
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:8137
    UQ_con; Ubiquitin-conjugating enzyme
  2. XM_005255540.2XP_005255597.1  SUMO-conjugating enzyme UBC9 isoform X1

    See identical proteins and their annotated locations for XP_005255597.1

    UniProtKB/TrEMBL
    B0QYN7
    Related
    ENSP00000384361.1, ENST00000402301.5
    Conserved Domains (2) summary
    COG5078
    Location:1137
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:8137
    UQ_con; Ubiquitin-conjugating enzyme
  3. XM_011522644.2XP_011520946.1  SUMO-conjugating enzyme UBC9 isoform X1

    See identical proteins and their annotated locations for XP_011520946.1

    UniProtKB/TrEMBL
    B0QYN7
    Conserved Domains (2) summary
    COG5078
    Location:1137
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:8137
    UQ_con; Ubiquitin-conjugating enzyme
  4. XM_017023640.1XP_016879129.1  SUMO-conjugating enzyme UBC9 isoform X2

    UniProtKB/Swiss-Prot
    P63279
    Related
    ENSP00000457064.1, ENST00000566587.5
    Conserved Domains (1) summary
    pfam00179
    Location:8152
    UQ_con; Ubiquitin-conjugating enzyme
  5. XM_005255541.4XP_005255598.1  SUMO-conjugating enzyme UBC9 isoform X1

    See identical proteins and their annotated locations for XP_005255598.1

    UniProtKB/TrEMBL
    B0QYN7
    Conserved Domains (2) summary
    COG5078
    Location:1137
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:8137
    UQ_con; Ubiquitin-conjugating enzyme
  6. XM_024450432.1XP_024306200.1  SUMO-conjugating enzyme UBC9 isoform X2

    Related
    ENSP00000384568.1, ENST00000406620.5
    Conserved Domains (1) summary
    pfam00179
    Location:8152
    UQ_con; Ubiquitin-conjugating enzyme
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