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    VPS15 ubiquitin-binding serine/threonine protein kinase VPS15 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852394, updated on 17-May-2024

    Summary

    Gene symbol
    VPS15
    Gene description
    ubiquitin-binding serine/threonine protein kinase VPS15
    Primary source
    FungiDB:YBR097W
    Locus tag
    YBR097W
    See related
    SGD:S000000301; AllianceGenome:SGD:S000000301; VEuPathDB:YBR097W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GRD8; VAC4; VPL19; VPS40; VPT15
    Summary
    Enables protein serine/threonine kinase activity and ubiquitin binding activity. Involved in several processes, including positive regulation of transcription elongation from RNA polymerase II promoter; protein localization to organelle; and vacuole inheritance. Located in nucleus-vacuole junction and vacuole-isolation membrane contact site. Part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Orthologous to human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See VPS15 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (436951..441315)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Rxt2p Neighboring gene uncharacterized protein Neighboring gene Mms4p Neighboring gene Hsp70 nucleotide exchange factor FES1

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autophagy of peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to potassium ion starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in late endosome to vacuole transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in late endosome to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pexophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein retention in Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vacuole inheritance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-binding serine/threonine protein kinase VPS15
    NP_009655.2
    • Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      436951..441315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178445.2NP_009655.2  TPA: ubiquitin-binding serine/threonine protein kinase VPS15 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009655.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ98, P22219
      UniProtKB/TrEMBL
      A0A8H4F7W6, G2W9A4, N1P8E3
      Conserved Domains (4) summary
      cd13980
      Location:26304
      STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
      sd00044
      Location:511538
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:10831127
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10801312
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...