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    BAIAP2 BAI1 associated protein 2 [ Homo sapiens (human) ]

    Gene ID: 10458, updated on 12-Aug-2018

    Summary

    Official Symbol
    BAIAP2provided by HGNC
    Official Full Name
    BAI1 associated protein 2provided by HGNC
    Primary source
    HGNC:HGNC:947
    See related
    Ensembl:ENSG00000175866 MIM:605475; Vega:OTTHUMG00000177698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAP2; FLAF3; IRSP53
    Summary
    The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
    Expression
    Broad expression in brain (RPKM 10.7), skin (RPKM 9.8) and 23 other tissues See more
    Orthologs

    Genomic context

    See BAIAP2 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (81035131..81117432)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79008944..79091232)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100129503 Neighboring gene BAIAP2 divergent transcript Neighboring gene uncharacterized LOC107987250 Neighboring gene apoptosis associated tyrosine kinase Neighboring gene microRNA 3065 Neighboring gene microRNA 657 Neighboring gene microRNA 338

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 VLP production/release from Jurkat T lymphocytes requires an intact RAC1-WASF2-BAIAP2-ARP3 pathway as demonstrated by siRNA knockdown experiments PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Downregulation of the Wave2 signaling complex (Tiam-1, Abl, Rac, IRSp53, Wave2, and Arp3) with siRNA reduces HIV-1 Env-mediated cell-cell fusion and virus-cell fusion PubMed
    Pr55(Gag) gag HIV-1 Gag is required by RAC1-WASF2-BAIAP2-ARP3 pathway for HIV VLP production/release from Jurkat T lymphocytes PubMed
    gag HIV-1 Gag intracellular localization is modulated by WASF2 and BAIAP2 as demonstrated by double siRNA knockdowns of these cellular proteins (in Jurkat T cells) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    cadherin binding involved in cell-cell adhesion HDA PubMed 
    cytoskeletal adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proline-rich region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C-terminus binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription cofactor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin crosslink formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin filament bundle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axonogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to L-glutamate IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    modification of synaptic structure, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of actin cytoskeleton reorganization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to synapse IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of modification of postsynaptic actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction HDA PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    excitatory synapse IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection branch point IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection terminus IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    postsynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density, intracellular component IEA
    Inferred from Electronic Annotation
    more info
     
    presynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    brain-specific angiogenesis inhibitor 1-associated protein 2
    Names
    IRS-58
    IRSp53/58
    fas ligand-associated factor 3
    insulin receptor substrate of 53 kDa
    insulin receptor substrate p53/p58
    insulin receptor substrate protein of 53 kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029486.1 RefSeqGene

      Range
      5001..87286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144888.1NP_001138360.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001138360.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) shares identical sequence with variants 1, 2 and 3, but diverges after amino acid 511 resulting in a distinct 23 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as variant M.
      Source sequence(s)
      AC115099, BC002495, CB153324
      Consensus CDS
      CCDS45806.1
      UniProtKB/Swiss-Prot
      Q9UQB8
      Related
      ENSP00000401022.2, OTTHUMP00000257470, ENST00000428708.6, OTTHUMT00000438549
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    2. NM_006340.2NP_006331.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 3

      See identical proteins and their annotated locations for NP_006331.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) shares identical sequence with variants 1, 2 and 4, but diverges after amino acid 511 resulting in a distinct 9 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as BAP2-beta or variant T.
      Source sequence(s)
      AB015020, AC115099, BC002495, CB153324
      Consensus CDS
      CCDS11776.1
      UniProtKB/Swiss-Prot
      Q9UQB8
      Related
      ENSP00000413069.3, OTTHUMP00000257536, ENST00000435091.7, OTTHUMT00000438552
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    3. NM_017450.2NP_059344.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_059344.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) shares identical sequence with variants 2, 3 and 4, but diverges after amino acid 511 resulting in a distinct 10 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as BAP2-alpha, short form, or variant S.
      Source sequence(s)
      AC115099, BC002495, CB153324
      Consensus CDS
      CCDS11777.1
      UniProtKB/Swiss-Prot
      Q9UQB8
      Related
      ENSP00000315685.7, OTTHUMP00000257469, ENST00000321280.11, OTTHUMT00000438547
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    4. NM_017451.2NP_059345.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform 2

      See identical proteins and their annotated locations for NP_059345.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) shares identical sequence with variants 1, 3 and 4, but diverges after amino acid 511 resulting in a distinct 41 amino acid sequence at the C-terminus. This transcript variant is alternatively referred to as the long form or variant L.
      Source sequence(s)
      AC115099, BC002495, CB153324
      Consensus CDS
      CCDS11775.1
      UniProtKB/Swiss-Prot
      Q9UQB8
      Related
      ENSP00000316338.6, OTTHUMP00000257471, ENST00000321300.10, OTTHUMT00000438553
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:377435
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      81035131..81117432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450534.1XP_024306302.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X10

      Conserved Domains (2) summary
      cd11915
      Location:378436
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:95237
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_006721636.1XP_006721699.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X5

      See identical proteins and their annotated locations for XP_006721699.1

      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:411469
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    3. XM_011524194.1XP_011522496.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1

      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:411469
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    4. XM_005256945.1XP_005257002.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X6

      UniProtKB/TrEMBL
      I3L4C2
      Related
      ENSP00000461144.1, OTTHUMP00000257535, ENST00000575245.5, OTTHUMT00000438551
      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:410468
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    5. XM_005256943.1XP_005257000.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2

      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:410468
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    6. XM_006721637.2XP_006721700.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X7

      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:378436
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    7. XM_011524193.1XP_011522495.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X5

      See identical proteins and their annotated locations for XP_011522495.1

      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:411469
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    8. XM_006721635.1XP_006721698.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X3

      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:411469
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    9. XM_005256944.1XP_005257001.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X4

      Conserved Domains (2) summary
      cd07646
      Location:5269
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:410468
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    10. XM_005256948.3XP_005257005.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X9

      See identical proteins and their annotated locations for XP_005257005.1

      UniProtKB/Swiss-Prot
      Q9UQB8
      Conserved Domains (2) summary
      cd07646
      Location:5236
      I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53
      cd11915
      Location:378436
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    11. XM_017024017.1XP_016879506.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X8

    12. XM_017024018.1XP_016879507.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X11

      Conserved Domains (2) summary
      cd11915
      Location:300358
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1158
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    13. XM_024450535.1XP_024306303.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X11

      Conserved Domains (2) summary
      cd11915
      Location:300358
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
      cl12013
      Location:1158
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    14. XM_017024019.1XP_016879508.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X12

      Conserved Domains (1) summary
      cd11915
      Location:135193
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    15. XM_011524195.1XP_011522497.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X12

      See identical proteins and their annotated locations for XP_011522497.1

      Conserved Domains (1) summary
      cd11915
      Location:135193
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    16. XM_011524196.1XP_011522498.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X12

      See identical proteins and their annotated locations for XP_011522498.1

      Conserved Domains (1) summary
      cd11915
      Location:135193
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
    17. XM_011524197.1XP_011522499.1  brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X13

      Conserved Domains (1) summary
      cd11915
      Location:134192
      SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
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