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    mex-6 Zinc finger protein mex-6 [ Caenorhabditis elegans ]

    Gene ID: 174504, updated on 5-May-2024

    Summary

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    Gene symbol
    mex-6
    Gene description
    Zinc finger protein mex-6
    Primary source
    WormBase:WBGene00003231
    Locus tag
    CELE_AH6.5
    See related
    AllianceGenome:WB:WBGene00003231
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables mRNA 3'-UTR binding activity; protein domain specific binding activity; and protein kinase binding activity. Involved in regulation of protein localization. Located in P granule. Is expressed in AB; ABa; ABp; and germ line. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (9524174..9526359)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Serpentine receptor class alpha-1 Neighboring gene PP_kinase_C domain-containing protein Neighboring gene pseudo Neighboring gene Serpentine receptor class alpha-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5. Pagano JM, et al. J Biol Chem, 2007 Mar 23. PMID 17264081
    2. Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases. Cuenca AA, et al. Development, 2003 Apr. PMID 12588843, Free PMC Article
    3. Polarity-dependent asymmetric distribution and MEX-5/6-mediated translational activation of the Era-1 mRNA in C. elegans embryos. Spiró Z, et al. PLoS One, 2015. PMID 25821955, Free PMC Article
    4. Translational repression restricts expression of the C. elegans Nanos homolog NOS-2 to the embryonic germline. D'Agostino I, et al. Dev Biol, 2006 Apr 1. PMID 16499902
    5. Single-molecule dynamics of the P granule scaffold MEG-3 in the Caenorhabditis elegans zygote. Wu Y, et al. Mol Biol Cell, 2019 Feb 1. PMID 30540524, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polo kinases, via their polo box domains, bind to and regulate the activity of two key polarity proteins, MEX-5 and MEX-6.
      Title: Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of protein localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc finger protein mex-6
    NP_496043.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9524174..9526359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063642.7 → NP_496043.1  Zinc finger protein mex-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496043.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09436
      Conserved Domains (3) summary
      COG5063
      Location:157 → 359
      CTH1; CCCH-type Zn-finger protein [General function prediction only]
      pfam00642
      Location:318 → 345
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03153
      Location:53 → 245
      TFIIA; Transcription factor IIA, alpha/beta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09436.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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