U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ZNF654 zinc finger protein 654 [ Homo sapiens (human) ]

    Gene ID: 55279, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ZNF654provided by HGNC
    Official Full Name
    zinc finger protein 654provided by HGNC
    Primary source
    HGNC:HGNC:25612
    See related
    Ensembl:ENSG00000175105 AllianceGenome:HGNC:25612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 4.4), thyroid (RPKM 4.0) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    3p11.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (88059255..88144660)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (88135096..88220495)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (88108405..88193810)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 1F Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:87963222-87964421 Neighboring gene RNA, U6atac small nuclear 6, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14545 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14546 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:88094831-88096030 Neighboring gene uncharacterized LOC128031834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14547 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:88108555-88109114 Neighboring gene CGG triplet repeat binding protein 1 Neighboring gene chromobox 5 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:88198041-88198618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20117 Neighboring gene chromosome 3 open reading frame 38 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20120 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:88279578-88280777 Neighboring gene uncharacterized LOC105377202 Neighboring gene ATP binding cassette subfamily F member 2 pseudogene 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Perry JR, et al. Nature, 2014 Oct 2. PMID 25231870, Free PMC Article
    2. Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression. Kim JS, et al. J Biol Chem, 2019 May 31. PMID 31010829, Free PMC Article
    3. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ10997, FLJ21142

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    zinc finger protein 654
    Names
    melanoma-associated antigen

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001350134.2 → NP_001337063.1  zinc finger protein 654 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AA767937, AC119733, AC128650
      Consensus CDS
      CCDS87110.1
      UniProtKB/Swiss-Prot
      A0A1B0GWA0, Q8IZM8, Q9H791, Q9NV14
      Related
      ENSP00000490842.1, ENST00000636215.2
      Conserved Domains (2) summary
      sd00017
      Location:789 → 809
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:547 → 566
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001350135.2 → NP_001337064.1  zinc finger protein 654 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA767937, AC119733, AC128650
      Conserved Domains (2) summary
      sd00017
      Location:676 → 696
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam08580
      Location:757 → 957
      KAR9; Yeast cortical protein KAR9

    3. NM_001350136.2 → NP_001337065.1  zinc finger protein 654 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AA767937, AC119733, AC128650
      Conserved Domains (2) summary
      sd00017
      Location:577 → 597
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam08580
      Location:658 → 858
      KAR9; Yeast cortical protein KAR9

    4. NM_001350137.2 → NP_001337066.1  zinc finger protein 654 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AA767937, AC119733, AC128650
      Conserved Domains (2) summary
      sd00017
      Location:515 → 535
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam08580
      Location:596 → 796
      KAR9; Yeast cortical protein KAR9

    5. NM_001366093.1 → NP_001353022.1  zinc finger protein 654 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119733, AC128650
      Conserved Domains (2) summary
      sd00017
      Location:577 → 597
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam08580
      Location:658 → 858
      KAR9; Yeast cortical protein KAR9

    6. NM_001366095.1 → NP_001353024.1  zinc finger protein 654 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119733, AC128650
      Conserved Domains (2) summary
      sd00017
      Location:577 → 597
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam08580
      Location:658 → 858
      KAR9; Yeast cortical protein KAR9

    7. NM_001366096.1 → NP_001353025.1  zinc finger protein 654 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119733, AC128650
      Conserved Domains (2) summary
      sd00017
      Location:577 → 597
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam08580
      Location:658 → 858
      KAR9; Yeast cortical protein KAR9

    8. NM_001366097.1 → NP_001353026.1  zinc finger protein 654 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC119733, AC128650
      Conserved Domains (2) summary
      sd00017
      Location:515 → 535
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam08580
      Location:596 → 796
      KAR9; Yeast cortical protein KAR9

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      88059255..88144660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006789.3 → XP_016862278.1  zinc finger protein 654 isoform X1

    2. XM_017006791.3 → XP_016862280.1  zinc finger protein 654 isoform X2

    3. XM_047448514.1 → XP_047304470.1  zinc finger protein 654 isoform X3

    4. XM_024453623.2 → XP_024309391.1  zinc finger protein 654 isoform X4

      Conserved Domains (4) summary
      sd00017
      Location:515 → 535
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:273 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam08580
      Location:596 → 796
      KAR9; Yeast cortical protein KAR9
      pfam15909
      Location:543 → 595
      zf-C2H2_8; C2H2-type zinc ribbon

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      88135096..88220495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347170.1 → XP_054203145.1  zinc finger protein 654 isoform X1

    2. XM_054347171.1 → XP_054203146.1  zinc finger protein 654 isoform X2

    3. XM_054347172.1 → XP_054203147.1  zinc finger protein 654 isoform X3

    4. XM_054347173.1 → XP_054203148.1  zinc finger protein 654 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018293.2: Suppressed sequence

      Description
      NM_018293.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

    2. NM_032198.1: Suppressed sequence

      Description
      NM_032198.1: This RefSeq was temporarily suppressed because the CDS was partial.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZM8.4 GenPept UniProtKB/Swiss-Prot:Q8IZM8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous