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    rme-1 Dynamin-type G domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179010, updated on 25-Apr-2024

    Summary

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    Gene symbol
    rme-1
    Gene description
    Dynamin-type G domain-containing protein
    Primary source
    WormBase:WBGene00004373
    Locus tag
    CELE_W06H8.1
    See related
    AllianceGenome:WB:WBGene00004373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ATP hydrolysis activity and protein domain specific binding activity. Involved in several processes, including endocytic recycling; lipid tube assembly involved in organelle fission; and positive regulation of necrotic cell death. Located in recycling endosome membrane. Is expressed in coelomocyte; germ line; gonad; intestine; and pharynx. Orthologous to several human genes including EHD1 (EH domain containing 1) and EHD3 (EH domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    12
    Sequence:
    Chromosome: V; NC_003283.11 (6208885..6217664)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Seven TM Receptor Neighboring gene ncRNA Neighboring gene BHLH domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of vacuoles containing extraintestinal differentiated forms of Legionella pneumophila in colonized Caenorhabditis elegans soil nematodes. Hellinga JR, et al. Microbiologyopen, 2015 Aug. PMID 26131925, Free PMC Article
    2. Multicolor bleach-rate imaging enlightens in vivo sterol transport. Wüstner D, et al. Commun Integr Biol, 2010 Jul. PMID 20798830, Free PMC Article
    3. Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling. Grant B, et al. Nat Cell Biol, 2001 Jun. PMID 11389442
    4. The plasma membrane calcium ATPase MCA-3 is required for clathrin-mediated endocytosis in scavenger cells of Caenorhabditis elegans. Bednarek EM, et al. Traffic, 2007 May. PMID 17343680
    5. MAA-1, a novel acyl-CoA-binding protein involved in endosomal vesicle transport in Caenorhabditis elegans. Larsen MK, et al. Mol Biol Cell, 2006 Oct. PMID 16870706, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid tube assembly involved in organelle fission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dynamin-type G domain-containing protein
    NP_001024194.1
    • Confirmed by transcript evidence
    NP_001024195.1
    • Confirmed by transcript evidence
    NP_001024196.1
    • Confirmed by transcript evidence
    NP_001343865.1
    • Confirmed by transcript evidence
    NP_001343866.1
    • Confirmed by transcript evidence
    NP_001343867.1
    • Confirmed by transcript evidence
    NP_001367910.1
    • Confirmed by transcript evidence
    NP_001379996.1
    • Confirmed by transcript evidence
    NP_001379997.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6208885..6217664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029023.4 → NP_001024194.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024194.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEU7
      Conserved Domains (4) summary
      smart00027
      Location:481 → 574
      EH; Eps15 homology domain
      cd09913
      Location:94 → 334
      EHD; Eps15 homology domain (EHD), C-terminal domain
      cd00052
      Location:492 → 556
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam16880
      Location:58 → 90
      EHD_N; N-terminal EH-domain containing protein

    2. NM_001029025.7 → NP_001024196.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024196.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WSP1
      Conserved Domains (4) summary
      smart00027
      Location:505 → 598
      EH; Eps15 homology domain
      cd09913
      Location:118 → 358
      EHD; Eps15 homology domain (EHD), C-terminal domain
      cd00052
      Location:516 → 580
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam16880
      Location:82 → 114
      EHD_N; N-terminal EH-domain containing protein

    3. NM_001392527.1 → NP_001379996.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KFZ3, Q9N5B7
      Conserved Domains (4) summary
      smart00027
      Location:678 → 771
      EH; Eps15 homology domain
      cd09913
      Location:291 → 531
      EHD; Eps15 homology domain (EHD), C-terminal domain
      pfam16880
      Location:255 → 287
      EHD_N; N-terminal EH-domain containing protein
      pfam18150
      Location:519 → 625
      DUF5600; Domain of unknown function (DUF5600)

    4. NM_001380664.2 → NP_001367910.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECC3, Q7KFZ3
      Conserved Domains (4) summary
      smart00027
      Location:683 → 776
      EH; Eps15 homology domain
      cd09913
      Location:291 → 531
      EHD; Eps15 homology domain (EHD), C-terminal domain
      pfam16880
      Location:255 → 287
      EHD_N; N-terminal EH-domain containing protein
      pfam18150
      Location:519 → 625
      DUF5600; Domain of unknown function (DUF5600)

    5. NM_001356657.3 → NP_001343865.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C3Z4
      Conserved Domains (3) summary
      smart00027
      Location:505 → 598
      EH; Eps15 homology domain
      cd09913
      Location:113 → 353
      EHD; Eps15 homology domain (EHD), C-terminal domain
      pfam16880
      Location:78 → 109
      EHD_N; N-terminal EH-domain containing protein

    6. NM_001356658.3 → NP_001343866.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C3S7
      Conserved Domains (3) summary
      smart00027
      Location:500 → 593
      EH; Eps15 homology domain
      cd09913
      Location:113 → 353
      EHD; Eps15 homology domain (EHD), C-terminal domain
      pfam16880
      Location:78 → 109
      EHD_N; N-terminal EH-domain containing protein

    7. NM_001029024.5 → NP_001024195.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024195.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFP1
      Conserved Domains (4) summary
      smart00027
      Location:468 → 561
      EH; Eps15 homology domain
      cd09913
      Location:76 → 316
      EHD; Eps15 homology domain (EHD), C-terminal domain
      cd00052
      Location:479 → 543
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam16880
      Location:40 → 72
      EHD_N; N-terminal EH-domain containing protein

    8. NM_001356659.4 → NP_001343867.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C352
      Conserved Domains (3) summary
      smart00027
      Location:452 → 545
      EH; Eps15 homology domain
      cd09913
      Location:60 → 300
      EHD; Eps15 homology domain (EHD), C-terminal domain
      pfam16880
      Location:25 → 56
      EHD_N; N-terminal EH-domain containing protein

    9. NM_001392528.1 → NP_001379997.1  Dynamin-type G domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86S80
      Conserved Domains (4) summary
      smart00027
      Location:447 → 540
      EH; Eps15 homology domain
      cd09913
      Location:60 → 300
      EHD; Eps15 homology domain (EHD), C-terminal domain
      pfam16880
      Location:24 → 56
      EHD_N; N-terminal EH-domain containing protein
      pfam18150
      Location:288 → 394
      DUF5600; Domain of unknown function (DUF5600)
    Nucleotide Protein
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