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    ANPEP alanyl aminopeptidase, membrane [ Homo sapiens (human) ]

    Gene ID: 290, updated on 31-Mar-2024

    Summary

    Official Symbol
    ANPEPprovided by HGNC
    Official Full Name
    alanyl aminopeptidase, membraneprovided by HGNC
    Primary source
    HGNC:HGNC:500
    See related
    Ensembl:ENSG00000166825 MIM:151530; AllianceGenome:HGNC:500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APN; AP-M; AP-N; CD13; LAP1; P150; PEPN; hAPN; GP150
    Summary
    Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma. [provided by RefSeq, Apr 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
    Expression
    Biased expression in duodenum (RPKM 1193.1), small intestine (RPKM 1007.5) and 5 other tissues See more
    Orthologs
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    Genomic context

    See ANPEP in Genome Data Viewer
    Location:
    15q26.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (89784895..89814852, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (87540783..87570713, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90328126..90358084, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6805 Neighboring gene mitochondrial ribosomal protein L15 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90310867-90311584 Neighboring gene uncharacterized LOC124903550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10055 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:90326293-90326955 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:90326956-90327617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90327618-90328280 Neighboring gene mesoderm posterior bHLH transcription factor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90335518-90336018 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:90347169-90348368 Neighboring gene ANPEP proximal promoter Neighboring gene FOXA motif-containing MPRA enhancer 170 Neighboring gene ANPEP distal promoter Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90365008-90365508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90365509-90366009 Neighboring gene uncharacterized LOC124903551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90367927-90368600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90370583-90371474 Neighboring gene ARPIN-AP3S2 readthrough Neighboring gene uncharacterized LOC124903552 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:90380077-90381276 Neighboring gene adaptor related protein complex 3 subunit sigma 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aminopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metallopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    aminopeptidase N
    Names
    alanyl (membrane) aminopeptidase
    aminopeptidase M
    membrane alanyl aminopeptidase
    microsomal aminopeptidase
    myeloid plasma membrane glycoprotein CD13
    NP_001141.2
    NP_001368852.1
    NP_001368853.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001150.3NP_001141.2  aminopeptidase N precursor

      See identical proteins and their annotated locations for NP_001141.2

      Status: REVIEWED

      Source sequence(s)
      AB209918, AC018988, AC079075, BC058928, BQ879097
      Consensus CDS
      CCDS10356.1
      UniProtKB/Swiss-Prot
      P15144, Q16728, Q6GT90, Q8IUK3, Q8IVH3, Q9UCE0
      UniProtKB/TrEMBL
      Q59E93
      Related
      ENSP00000300060.6, ENST00000300060.7
      Conserved Domains (2) summary
      cd09601
      Location:84545
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:619946
      ERAP1_C; ERAP1-like C-terminal domain
    2. NM_001381923.1NP_001368852.1  aminopeptidase N

      Status: REVIEWED

      Source sequence(s)
      AC018988, AC079075
      Consensus CDS
      CCDS10356.1
      UniProtKB/Swiss-Prot
      P15144, Q16728, Q6GT90, Q8IUK3, Q8IVH3, Q9UCE0
      UniProtKB/TrEMBL
      Q59E93
      Related
      ENSP00000453413.2, ENST00000560137.2
      Conserved Domains (2) summary
      cd09601
      Location:84545
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:619946
      ERAP1_C; ERAP1-like C-terminal domain
    3. NM_001381924.1NP_001368853.1  aminopeptidase N

      Status: REVIEWED

      Source sequence(s)
      AC018988, AC079075
      Consensus CDS
      CCDS10356.1
      UniProtKB/Swiss-Prot
      P15144, Q16728, Q6GT90, Q8IUK3, Q8IVH3, Q9UCE0
      UniProtKB/TrEMBL
      Q59E93
      Conserved Domains (2) summary
      cd09601
      Location:84545
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:619946
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      89784895..89814852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      87540783..87570713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)