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Anpep alanyl (membrane) aminopeptidase [ Mus musculus (house mouse) ]

Gene ID: 16790, updated on 31-Jan-2019

Summary

Official Symbol
Anpepprovided by MGI
Official Full Name
alanyl (membrane) aminopeptidaseprovided by MGI
Primary source
MGI:MGI:5000466
See related
Ensembl:ENSMUSG00000039062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Apn; AP-M; AP-N; Cd13; P150
Expression
Biased expression in large intestine adult (RPKM 1188.9), duodenum adult (RPKM 786.8) and 2 other tissues See more
Orthologs

Genomic context

See Anpep in Genome Data Viewer
Location:
7; 7 D2
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (79821803..79848189, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (86966689..86987238, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene mesoderm posterior 1 Neighboring gene mesoderm posterior 2 Neighboring gene adaptor-related protein complex 3, sigma 2 subunit Neighboring gene actin-related protein 2/3 complex inhibitor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
 
peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide catabolic process ISO
Inferred from Sequence Orthology
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
brush border membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aminopeptidase N
Names
alanyl aminopeptidase
aminopeptidase M
aminopeptidase N/CD13
membrane protein p161
microsomal aminopeptidase
NP_032512.2
XP_006540741.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008486.3NP_032512.2  aminopeptidase N

    See identical proteins and their annotated locations for NP_032512.2

    Status: VALIDATED

    Source sequence(s)
    AI848985, AK143746, AK171427, BY135516
    Consensus CDS
    CCDS21388.1
    UniProtKB/Swiss-Prot
    P97449
    Related
    ENSMUSP00000035943.6, ENSMUST00000049004.7
    Conserved Domains (3) summary
    cd09601
    Location:84550
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:75479
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:619942
    ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    79821803..79848189 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540678.3XP_006540741.1  aminopeptidase N isoform X1

    UniProtKB/Swiss-Prot
    P97449
    Related
    ENSMUSP00000103015.1, ENSMUST00000107392.7
    Conserved Domains (3) summary
    cd09601
    Location:84550
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:75479
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:619942
    ERAP1_C; ERAP1-like C-terminal domain
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