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Anpep alanyl aminopeptidase, membrane [ Mus musculus (house mouse) ]

Gene ID: 16790, updated on 12-May-2024

Summary

Official Symbol
Anpepprovided by MGI
Official Full Name
alanyl aminopeptidase, membraneprovided by MGI
Primary source
MGI:MGI:5000466
See related
Ensembl:ENSMUSG00000039062 AllianceGenome:MGI:5000466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Apn; AP-M; AP-N; Cd13; P150
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of renal sodium excretion; peptide catabolic process; and proteolysis. Predicted to act upstream of or within angiogenesis and cell differentiation. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and sensory organ. Orthologous to human ANPEP (alanyl aminopeptidase, membrane). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 1188.9), duodenum adult (RPKM 786.8) and 2 other tissues See more
Orthologs
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Genomic context

See Anpep in Genome Data Viewer
Location:
7 D2; 7 45.19 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79471551..79497958, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79821803..79848210, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mesoderm posterior 1 Neighboring gene mesoderm posterior 2 Neighboring gene adaptor-related protein complex 3, sigma 2 subunit Neighboring gene STARR-seq mESC enhancer starr_19292 Neighboring gene RIKEN cDNA 5430400D12 gene Neighboring gene actin-related protein 2/3 complex inhibitor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aminopeptidase N
Names
alanyl (membrane) aminopeptidase
alanyl aminopeptidase
aminopeptidase M
aminopeptidase N/CD13
membrane protein p161
microsomal aminopeptidase
NP_032512.2
XP_036008613.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008486.3NP_032512.2  aminopeptidase N

    See identical proteins and their annotated locations for NP_032512.2

    Status: VALIDATED

    Source sequence(s)
    AI848985, AK143746, AK171427, BY135516
    Consensus CDS
    CCDS21388.1
    UniProtKB/Swiss-Prot
    P97449, Q91YH8, Q99K63
    UniProtKB/TrEMBL
    Q3UP74
    Related
    ENSMUSP00000103015.2, ENSMUST00000107392.8
    Conserved Domains (2) summary
    cd09601
    Location:84545
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:618945
    ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79471551..79497958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152720.1XP_036008613.1  aminopeptidase N isoform X1

    UniProtKB/Swiss-Prot
    P97449, Q91YH8, Q99K63
    UniProtKB/TrEMBL
    Q3UP74
    Related
    ENSMUSP00000035943.7, ENSMUST00000049004.8
    Conserved Domains (2) summary
    cd09601
    Location:84545
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:618945
    ERAP1_C; ERAP1-like C-terminal domain