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    RPT4A regulatory particle triple-A ATPase 4A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834316, updated on 7-Sep-2023

    Summary

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    Gene symbol
    RPT4A
    Gene description
    regulatory particle triple-A ATPase 4A
    Primary source
    Araport:AT5G43010
    Locus tag
    AT5G43010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MBD2.21; MBD2_21; regulatory particle triple-A ATPase 4A
    Summary
    26S proteasome AAA-ATPase subunit RPT4a (RPT4a) mRNA
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (17248290..17251200, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene thioredoxin 3 Neighboring gene ubiquitin-conjugating enzyme 18 Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Leucine-rich repeat protein kinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional analysis of the six regulatory particle triple-A ATPase subunits from the Arabidopsis 26S proteasome. Fu H, et al. Plant J, 1999 Jun. PMID 10417703
    2. A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Glickman MH, et al. Cell, 1998 Sep 4. PMID 9741626
    3. Subunit interaction maps for the regulatory particle of the 26S proteasome and the COP9 signalosome. Fu H, et al. EMBO J, 2001 Dec 17. PMID 11742986, Free PMC Article
    4. Structure and functional analysis of the 26S proteasome subunits from plants. Fu H, et al. Mol Biol Rep, 1999 Apr. PMID 10363660
    5. Affinity purification of the Arabidopsis 26 S proteasome reveals a diverse array of plant proteolytic complexes. Book AJ, et al. J Biol Chem, 2010 Aug 13. PMID 20516081, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_123667.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plant-type cell wall HDA PubMed 
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle, base subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulatory particle triple-A ATPase 4A
    NP_199115.1
    • regulatory particle triple-A ATPase 4A (RPT4A); FUNCTIONS IN: ATPase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome regulatory particle, base subcomplex, proteasome complex, cell wall, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA-type, conserved site (InterPro:IPR003960), 26S proteasome subunit P45 (InterPro:IPR005937); BEST Arabidopsis thaliana protein match is: AAA-type ATPase family protein (TAIR:AT1G45000.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17248290..17251200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123667.4 → NP_199115.1  regulatory particle triple-A ATPase 4A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199115.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q570H6, Q9SEI3
      UniProtKB/TrEMBL
      A0A178UH77, A0A5S9YAF0, A0A654G7H5
      Conserved Domains (1) summary
      COG1222
      Location:17 → 390
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SEI3.1

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