YUC1 Flavin-binding monooxygenase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: YUC1
Gene description: Flavin-binding monooxygenase family protein
Primary source: Araport:AT4G32540
Locus tag: AT4G32540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: L23H3.20; L23H3_20; YUC; YUCCA; YUCCA 1
Summary: Mutant has elevated levels of free IAA in dominant mutant allele; Flavin Monooxygenase-Like Enzyme; Auxin Biosynthesis
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Genomic context

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Location:: chromosome: 4

Exon count:: 4

Sequence:: Chromosome: 4; NC_003075.7 (15700829..15703000)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The viral suppressor HCPro decreases DNA methylation and activates auxin biosynthesis genes.
Title: The viral suppressor HCPro decreases DNA methylation and activates auxin biosynthesis genes.
Data show that endoplasmic reticulum (ER) membrane anchored YUC proteins can mainly be found in roots, while cytosolic proteins are more abundant in the shoot.
Title: Bioinformatics Analysis of Phylogeny and Transcription of TAA/YUC Auxin Biosynthetic Genes.
Studies indicate that YUCCA, a flavin-containing monooxygenase (YUC), catalyzes the last step of conversion from indole-3-pyruvate (IPyA) to indole-3-acetic acid (IAA).
Title: Small-molecule auxin inhibitors that target YUCCA are powerful tools for studying auxin function.
The induction of the YUCCA (YUC) genes increases Phenylacetic acid (PAA) metabolite levels in Arabidopsis, indicating that YUC flavin-containing monooxygenases may play a role in PAA biosynthesis.
Title: Distinct Characteristics of Indole-3-Acetic Acid and Phenylacetic Acid, Two Common Auxins in Plants.
Yucasin is a potent inhibitor of YUC enzymes that offers an effective tool for analyzing the contribution of Indole-3-acetic acid (IAA) biosynthesis via the indole-3-pyruvic acid (IPyA) pathway to plant development and physiological processes.
Title: Yucasin is a potent inhibitor of YUCCA, a key enzyme in auxin biosynthesis.
Expressions of YUCs in the leaf respond to the adaxial-abaxial juxtaposition, and that the activities of auxin mediate leaf margin development, which subsequently promotes blade outgrowth.
Title: YUCCA genes are expressed in response to leaf adaxial-abaxial juxtaposition and are required for leaf margin development.
The analysis indicated that YUCCAs and TAA1, working in the IPA-YUC auxin biosynthesis pathway, are associated with SE induction, and that the expression of three YUCCA genes (YUC1, YUC4 and YUC10) is associated with LEC2 activity.
Title: LEAFY COTYLEDON2 (LEC2) promotes embryogenic induction in somatic tissues of Arabidopsis, via YUCCA-mediated auxin biosynthesis.
YUCCAs (YUCs) encoding key enzymes in auxin biosynthesis are required for somatic embryo induction
Title: Induction of somatic embryos in Arabidopsis requires local YUCCA expression mediated by the down-regulation of ethylene biosynthesis.
Data indicate that mature YUCCA 1 (YUC1) auxin biosynthesis gene overexpressing plants have elevated auxin levels and enhanced susceptibility to Pseudomonas syringae strain DC3000.
Title: Auxin promotes susceptibility to Pseudomonas syringae via a mechanism independent of suppression of salicylic acid-mediated defenses.
YUCCA1 flavin monooxygenase functions in the indole-3-pyruvic acid branch of auxin biosynthesis
Title: The Arabidopsis YUCCA1 flavin monooxygenase functions in the indole-3-pyruvic acid branch of auxin biosynthesis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Homology

Orthologs from OrthoDB

NM_001342156.1

Supported by ESTs:

NM_119406.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables N,N-dimethylaniline monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables indole-3-pyruvate monooxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in auxin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within auxin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cotyledon development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inflorescence development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phyllome development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of flower development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of anatomical structure morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of leaf development	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: Flavin-binding monooxygenase family protein

NP_194980.1

YUCCA 1 (YUC1); FUNCTIONS IN: NADP or NADPH binding, oxidoreductase activity, FAD binding, flavin-containing monooxygenase activity; INVOLVED IN: in 7 processes; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: C globular stage, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Pyridine nucleotide-disulphide oxidoreductase, class-II (InterPro:IPR000103), FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Flavin-containing monooxygenase-like (InterPro:IPR020946); BEST Arabidopsis thaliana protein match is: Flavin-binding monooxygenase family protein (TAIR:AT5G11320.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

15700829..15703000

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119406.3 → NP_194980.1 Flavin-binding monooxygenase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194980.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SZY8

UniProtKB/TrEMBL

A0A178V499, A0A5S9XXY8, A0A654FUX5

Conserved Domains (1) summary

COG2072
Location:22 → 393

CzcO; Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism]
NM_001342156.1 → NP_001329230.1 Flavin-binding monooxygenase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V499, A0A1P8B730, A0A5S9XXY8