KEA2 K+ efflux antiporter 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Gene symbol: KEA2
Gene description: K+ efflux antiporter 2
Primary source: Araport:AT4G00630
Locus tag: AT4G00630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATKEA2; F6N23.15; F6N23_15; K+ efflux antiporter 2
Summary: Encodes a K(+)/H(+) antiporter that modulates monovalent cation and pH homeostasis in plant chloroplasts or plastids.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

Location:: chromosome: 4

Exon count:: 20

Sequence:: Chromosome: 4; NC_003075.7 (261246..268097, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Double mutations in the plastid K(+) exchange antiporter (KEA) transporters kea1kea2 and a single mutation that does not visibly affect chloroplast structure, kea3, impaired the rapid hyperosmotic-induced Ca(2+) responses.
Title: Rapid hyperosmotic-induced Ca2+ responses in Arabidopsis thaliana exhibit sensory potentiation and involvement of plastidial KEA transporters.
Results show that envelope K+/H+ Antiporters AtKEA1 and AtKEA2 transporters in specific microdomains of the inner envelope link local osmotic, ionic, and pH homeostasis to plastid division and thylakoid membrane formation.
Title: Envelope K+/H+ Antiporters AtKEA1 and AtKEA2 Function in Plastid Development.
role of inner envelope KEA1 and KEA2 and thylakoid KEA3 transporters in chloroplast osmoregulation, integrity, and ion and pH homeostasis
Title: Plastidial transporters KEA1, -2, and -3 are essential for chloroplast osmoregulation, integrity, and pH regulation in Arabidopsis.
AtKEA2 represents the founding member of a novel group of eukaryote K(+)/H(+) antiporters that modulate monovalent cation and pH homeostasis in plant chloroplasts or plastids
Title: Arabidopsis KEA2, a homolog of bacterial KefC, encodes a K(+)/H(+) antiporter with a chloroplast transit peptide.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_001203716.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables potassium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium:proton antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables proton transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chloroplast organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plastid gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plastid rRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within_positive_effect primary root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect reactive nitrogen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect regulation of cellular hyperosmotic salinity response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of pH	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of photosynthesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of photosynthesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of seedling development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to absence of light	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect response to sucrose	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: K+ efflux antiporter 2

NP_001190645.1

K+ efflux antiporter 2 (KEA2); FUNCTIONS IN: potassium:hydrogen antiporter activity, potassium ion transmembrane transporter activity; INVOLVED IN: potassium ion transport, cation transport, metabolic process, transmembrane transport; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: K+/H+ exchanger (InterPro:IPR004771), Cation/H+ exchanger (InterPro:IPR006153), NAD(P)-binding domain (InterPro:IPR016040), Regulator of K+ conductance, N-terminal (InterPro:IPR003148); BEST Arabidopsis thaliana protein match is: K+ efflux antiporter 1 (TAIR:AT1G01790.1).

NP_191972.6

K+ efflux antiporter 2 (KEA2); FUNCTIONS IN: potassium:hydrogen antiporter activity, potassium ion transmembrane transporter activity; INVOLVED IN: potassium ion transport, cation transport, metabolic process, transmembrane transport; LOCATED IN: chloroplast, membrane, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cation/H+ exchanger (InterPro:IPR006153), K+/H+ exchanger (InterPro:IPR004771), NAD(P)-binding domain (InterPro:IPR016040), Regulator of K+ conductance, N-terminal (InterPro:IPR003148); BEST Arabidopsis thaliana protein match is: K+ efflux antiporter 1 (TAIR:AT1G01790.1); Has 34304 Blast hits to 27699 proteins in 2887 species: Archae - 928; Bacteria - 15112; Metazoa - 9897; Fungi - 1524; Plants - 1371; Viruses - 95; Other Eukaryotes - 5377 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

261246..268097 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116288.7 → NP_191972.6 K+ efflux antiporter 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191972.6

Status: REVIEWED

UniProtKB/Swiss-Prot

O65272, O65273

UniProtKB/TrEMBL

A0A5S9XQF2, A0A654FKN7

Conserved Domains (2) summary

PRK02224
Location:118 → 388

PRK02224; DNA double-strand break repair Rad50 ATPase

PRK03562
Location:578 → 1098

PRK03562; glutathione-regulated potassium-efflux system protein KefC; Provisional
NM_001203716.1 → NP_001190645.1 K+ efflux antiporter 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190645.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XQF2, F4JHE9

Conserved Domains (7) summary

COG1226
Location:981 → 1153

Kch; Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism]

TIGR00932
Location:578 → 867

2a37; transporter, monovalent cation:proton antiporter-2 (CPA2) family

pfam00769
Location:243 → 446

ERM; Ezrin/radixin/moesin family

pfam02254
Location:989 → 1102

TrkA_N; TrkA-N domain

pfam05145
Location:596 → 957

AmoA; Putative ammonia monooxygenase

pfam16731
Location:143 → 304

GARP; Glutamic acid/alanine-rich protein of Trypanosoma

cl02488
Location:115 → 323

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...