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    MOS4 modifier of snc1,4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821343, updated on 7-Sep-2023

    Summary

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    Gene symbol
    MOS4
    Gene description
    modifier of snc1,4
    Primary source
    Araport:AT3G18165
    Locus tag
    AT3G18165
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    4; Modifier of snc1
    Summary
    Encodes MOS4 (Modifier of snc1, 4), a nuclear protein homologous to human Breast Cancer-Amplified Sequence (BCAS2). MOS4 interacts with AtCDC5 and PRL1. All three proteins are essential for plant innate immunity.
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (6223125..6225403)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RNI-like superfamily protein Neighboring gene peroxin 3-1 Neighboring gene Glycosyltransferase family 61 protein Neighboring gene ncRNA Neighboring gene Glycosyltransferase family 61 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cyclin L homolog MOS12 and the MOS4-associated complex are required for the proper splicing of plant resistance genes. Xu F, et al. Plant J, 2012 Jun. PMID 22248079
    2. Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms. Palma K, et al. Genes Dev, 2007 Jun 15. PMID 17575050, Free PMC Article
    3. Two putative RNA-binding proteins function with unequal genetic redundancy in the MOS4-associated complex. Monaghan J, et al. Plant Physiol, 2010 Dec. PMID 20943852, Free PMC Article
    4. Two Prp19-like U-box proteins in the MOS4-associated complex play redundant roles in plant innate immunity. Monaghan J, et al. PLoS Pathog, 2009 Jul. PMID 19629177, Free PMC Article
    5. Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5. Deng X, et al. Proc Natl Acad Sci U S A, 2016 May 10. PMID 27114555, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112699.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    modifier of snc1,4
    NP_566599.1
    • Modifier of snc1,4 (MOS4); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: defense response signaling pathway, resistance gene-independent, defense response signaling pathway, resistance gene-dependent, defense response to bacterium, defense response to fungus; LOCATED IN: nucleolus, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Breast carcinoma amplified sequence 2 (InterPro:IPR008409); Has 346 Blast hits to 346 proteins in 142 species: Archae - 0; Bacteria - 2; Metazoa - 155; Fungi - 78; Plants - 42; Viruses - 0; Other Eukaryotes - 69 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6223125..6225403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112699.3 → NP_566599.1  modifier of snc1,4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566599.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q949S9, Q9LV24
      UniProtKB/TrEMBL
      A0A178VC07, A0A5S9XDG9, A0A654F9C9
      Conserved Domains (1) summary
      pfam05700
      Location:28 → 234
      BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q949S9.1

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