CPC Homeodomain-like superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: CPC
Gene description: Homeodomain-like superfamily protein
Primary source: Araport:AT2G46410
Locus tag: AT2G46410
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CAPRICE; F11C10.10; MYB FAMILY TRANSCRIPTION FACTOR CPC
Summary: Nuclear-localized R3-type MYB transcription factor. Positive regulator of hair-cell differentiation. Preferentially transcribed in hairless cells. Moves from atrichoblasts into trichoblast via plasmodesmata in a tissue-specific mode. N-terminus and part of the Myb domain are required for this movement, with W76 playing a crucial role. Capability to increase the size-exclusion limit of plasmodesmata. Regulated by WEREWOLF.
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Genomic context

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Location:: chromosome: 2

Exon count:: 3

Sequence:: Chromosome: 2; NC_003071.7 (19049021..19050369, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Function of the TRY C-terminal region artificially fused with its homologous transcription factors inducing root hair differentiation in Arabidopsis.
Title: Function of the TRY C-terminal region artificially fused with its homologous transcription factors inducing root hair differentiation in Arabidopsis.
These results indicate that the maintenance of not only the S1 and S2 motifs but also the precise structure of CPC protein might be necessary for the cell-to-cell movement of CPC. Our results should help in further unraveling of the roles of these MYB transcription factors in root hair formation
Title: Effect of amino acid substitution of CAPRICE on cell-to-cell movement ability in Arabidopsis root epidermis.
that CPC, TRY and ETC1 are also involved in root hair formation at the root-hypocotyl junction.
Title: Root hair formation at the root-hypocotyl junction in CPC-LIKE MYB double and triple mutants of Arabidopsis.
In an intricate interplay between three partly redundant single R3 MYB proteins, CPC, ETC1, and TRY regulate several developmental, physiological and metabolic processes that are putatively located in different tissues.
Title: The paralogous R3 MYB proteins CAPRICE, TRIPTYCHON and ENHANCER OF TRY AND CPC1 play pleiotropic and partly non-redundant roles in the phosphate starvation response of Arabidopsis roots.
overexpression did not influence anthocyanin biosynthesis in tomato fruit peel
Title: Overexpressing CAPRICE and GLABRA3 did not change the anthocyanin content of tomato (Solanum lycopersicum) fruit peel.
Double mutant analysis reveal that wer and caprice (cpc) mutants, defective in core components of the epidermal patterning pathway, genetically interact with sab. This suggests that SAB may act on epidermal patterning upstream of WER and CPC.
Title: SABRE is required for stabilization of root hair patterning in Arabidopsis thaliana.
TRY, but not the related factor CPC, is responsible for the preferential SCM accumulation.
Title: TRIPTYCHON, not CAPRICE, participates in feedback regulation of SCM expression in the Arabidopsis root epidermis.
Localization of CPC in the nucleus requires the H-cell-expressed ENHANCER OF GLABRA3 (EGL3).
Title: Nuclear trapping controls the position-dependent localization of CAPRICE in the root epidermis of Arabidopsis.
Mutations in CPC or TRY delay flowering of cpl3 plants. A mutation in ETC1 did not further delay flowering but reduced plant size.
Title: Flowering is delayed by mutations in homologous genes CAPRICE and TRYPTICHON in the early flowering Arabidopsis cpl3 mutant.
AtMYC1 modulates the behaviour of GL1 by recruiting it from the nucleus to the cytoplasm, and AtMYC1 is recruited by TRY or CPC to the nucleus.
Title: Mutual control of intracellular localisation of the patterning proteins AtMYC1, GL1 and TRY/CPC in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_130205.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within plant epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of trichoblast fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stomatal complex formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Homeodomain-like superfamily protein

NP_182164.1

CAPRICE (CPC); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-related (InterPro:IPR012287), MYB-like (InterPro:IPR017877), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: Homeodomain-like superfamily protein (TAIR:AT5G53200.1); Has 2615 Blast hits to 2615 proteins in 179 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 2602; Viruses - 0; Other Eukaryotes - 13 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

19049021..19050369 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130205.2 → NP_182164.1 Homeodomain-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_182164.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O22059

UniProtKB/TrEMBL

A0A178VZ09, A0A5S9X7H7, A0A654F2G6

Conserved Domains (1) summary

PLN03212
Location:38 → 76

PLN03212; Transcription repressor MYB5; Provisional