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    DOP1B DOP1 leucine zipper like protein B [ Homo sapiens (human) ]

    Gene ID: 9980, updated on 5-Mar-2024

    Summary

    Official Symbol
    DOP1Bprovided by HGNC
    Official Full Name
    DOP1 leucine zipper like protein Bprovided by HGNC
    Primary source
    HGNC:HGNC:1291
    See related
    Ensembl:ENSG00000142197 MIM:604803; AllianceGenome:HGNC:1291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    21orf5; DOPEY2; C21orf5
    Summary
    Involved in cognition. Located in early endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon (RPKM 9.1), bone marrow (RPKM 8.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    21q22.12
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (36156824..36294274)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (34539677..34676829)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (37529122..37666572)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37506732-37507539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37507540-37508346 Neighboring gene CBR3 antisense RNA 1 Neighboring gene ribosomal protein S9 pseudogene 1 Neighboring gene carbonyl reductase 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37527648-37528315 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37528316-37528982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13281 Neighboring gene ribosomal protein L3 pseudogene 1 Neighboring gene uncharacterized LOC124905016 Neighboring gene Sharpr-MPRA regulatory region 3517 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37582868-37583802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37612237-37612736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37618057-37618558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18432 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13283 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:37668114-37668355 Neighboring gene serine and arginine rich splicing factor 9 pseudogene 1 Neighboring gene ribosomal protein S26 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoplasmic reticulum organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein dopey-2
    Names
    dopey family member 2
    homolog of yeast DOP1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320714.2NP_001307643.1  protein dopey-2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB023150, AP000689, AP000690, AP000691, AP000692, BP364624, BP365117, W15495
      Consensus CDS
      CCDS13643.1
      UniProtKB/Swiss-Prot
      D3DSG5, Q6PJQ7, Q9UEZ3, Q9Y3R5
      Related
      ENSP00000509598.1, ENST00000691173.1
      Conserved Domains (2) summary
      pfam04118
      Location:13308
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:19512107
      Dopey_N; Dopey, N-terminal
    2. NM_005128.4NP_005119.2  protein dopey-2

      See identical proteins and their annotated locations for NP_005119.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AJ237839, AP000689, AP000690, AP000691, BC012791, W15495
      Consensus CDS
      CCDS13643.1
      UniProtKB/Swiss-Prot
      D3DSG5, Q6PJQ7, Q9UEZ3, Q9Y3R5
      Related
      ENSP00000382104.3, ENST00000399151.3
      Conserved Domains (2) summary
      pfam04118
      Location:13308
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:19512107
      Dopey_N; Dopey, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      36156824..36294274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028509.2XP_016883998.1  protein dopey-2 isoform X1

    RNA

    1. XR_937581.4 RNA Sequence

      Related
      ENST00000685394.1
    2. XR_007067795.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      34539677..34676829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324968.1XP_054180943.1  protein dopey-2 isoform X1

    RNA

    1. XR_008485346.1 RNA Sequence

    2. XR_008485347.1 RNA Sequence