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Dop1b DOP1 leucine zipper like protein B [ Mus musculus (house mouse) ]

Gene ID: 70028, updated on 9-May-2024

Summary

Official Symbol
Dop1bprovided by MGI
Official Full Name
DOP1 leucine zipper like protein Bprovided by MGI
Primary source
MGI:MGI:1917278
See related
Ensembl:ENSMUSG00000022946 AllianceGenome:MGI:1917278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dopey2; C21orf5; mKIAA0933; 0610038M01Rik; 2610510B01Rik
Summary
Predicted to be involved in cognition. Predicted to act upstream of or within protein transport. Predicted to be located in early endosome membrane. Predicted to be active in endosome and trans-Golgi network. Is expressed in several structures, including early conceptus; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human DOP1B (DOP1 leucine zipper like protein B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 11.3), lung adult (RPKM 9.2) and 28 other tissues See more
Orthologs
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Genomic context

See Dop1b in Genome Data Viewer
Location:
16 C4; 16 54.63 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (93508795..93607476)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (93711907..93810588)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene carbonyl reductase 3 Neighboring gene STARR-positive B cell enhancer ABC_E5562 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:93711280-93711389 Neighboring gene STARR-positive B cell enhancer ABC_E1497 Neighboring gene STARR-seq mESC enhancer starr_41539 Neighboring gene predicted gene, 41501 Neighboring gene RIKEN cDNA 2310043M15 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:93798797-93799098 Neighboring gene STARR-positive B cell enhancer ABC_E7479 Neighboring gene predicted gene, 30881 Neighboring gene STARR-seq mESC enhancer starr_41543 Neighboring gene STARR-positive B cell enhancer ABC_E7480 Neighboring gene STARR-positive B cell enhancer ABC_E3176 Neighboring gene STARR-seq mESC enhancer starr_41545 Neighboring gene microrchidia 3 Neighboring gene STARR-positive B cell enhancer ABC_E3177 Neighboring gene chromatin assembly factor 1, subunit B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in Golgi to endosome transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic pattern specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein dopey-2
Names
dopey family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357118.1NP_001344047.1  protein dopey-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154449, AC168220
    Consensus CDS
    CCDS88972.1
    UniProtKB/TrEMBL
    A0A2I3BRZ2
    Related
    ENSMUSP00000154771.2, ENSMUST00000227156.2
    Conserved Domains (2) summary
    pfam04118
    Location:1186
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:18321980
    Dopey_N; Dopey, N-terminal
  2. NM_026700.2NP_080976.1  protein dopey-2 isoform 2

    See identical proteins and their annotated locations for NP_080976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons and has an alternate 3' end, as compared to variant 1. The encoded isoform 2 has a much shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK002808, AK147255, BY195296
    UniProtKB/TrEMBL
    Q9DCG4
    Conserved Domains (1) summary
    pfam04118
    Location:13176
    Dopey_N; Dopey, N-terminal
  3. NM_027293.1NP_081569.1  protein dopey-2 isoform 1

    See identical proteins and their annotated locations for NP_081569.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK147255, BC057081, BC075639, BE945779, BY195296
    Consensus CDS
    CCDS28343.1
    UniProtKB/Swiss-Prot
    E9QLV2, Q3UH78, Q3UHQ6, Q80TN8
    Related
    ENSMUSP00000044437.10, ENSMUST00000045004.11
    Conserved Domains (2) summary
    pfam04118
    Location:13308
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:19492097
    Dopey_N; Dopey, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    93508795..93607476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246143.1XP_011244445.1  protein dopey-2 isoform X1

    See identical proteins and their annotated locations for XP_011244445.1

    Conserved Domains (2) summary
    pfam04118
    Location:13304
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:19872135
    Dopey_N; Dopey, N-terminal
  2. XM_006523080.2XP_006523143.1  protein dopey-2 isoform X7

    Conserved Domains (2) summary
    pfam04118
    Location:13304
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:19502098
    Dopey_N; Dopey, N-terminal
  3. XM_011246145.2XP_011244447.1  protein dopey-2 isoform X2

    Conserved Domains (2) summary
    pfam04118
    Location:13304
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:19862134
    Dopey_N; Dopey, N-terminal
  4. XM_011246146.2XP_011244448.1  protein dopey-2 isoform X3

    Conserved Domains (2) summary
    pfam04118
    Location:13304
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:19752123
    Dopey_N; Dopey, N-terminal
  5. XM_017317127.2XP_017172616.1  protein dopey-2 isoform X4

    Conserved Domains (2) summary
    pfam04118
    Location:13304
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:19742122
    Dopey_N; Dopey, N-terminal
  6. XM_006523077.2XP_006523140.1  protein dopey-2 isoform X5

    Conserved Domains (2) summary
    pfam04118
    Location:13304
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:19622110
    Dopey_N; Dopey, N-terminal
  7. XM_017317128.2XP_017172617.1  protein dopey-2 isoform X6

    Conserved Domains (2) summary
    pfam04118
    Location:13304
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:19612109
    Dopey_N; Dopey, N-terminal
  8. XM_011246150.2XP_011244452.1  protein dopey-2 isoform X11

    Conserved Domains (1) summary
    pfam04118
    Location:13304
    Dopey_N; Dopey, N-terminal
  9. XM_036160109.1XP_036016002.1  protein dopey-2 isoform X8

    Conserved Domains (2) summary
    pfam04118
    Location:1186
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:18692095
    Dopey_N; Dopey, N-terminal
  10. XM_030249264.2XP_030105124.1  protein dopey-2 isoform X9

    Conserved Domains (1) summary
    cl04407
    Location:186
    Dopey_N; Dopey, N-terminal
  11. XM_030249265.2XP_030105125.1  protein dopey-2 isoform X10

    Conserved Domains (1) summary
    cl04407
    Location:16981924
    Dopey_N; Dopey, N-terminal
  12. XM_011246144.2XP_011244446.1  protein dopey-2 isoform X1

    See identical proteins and their annotated locations for XP_011244446.1

    Conserved Domains (2) summary
    pfam04118
    Location:13304
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:19872135
    Dopey_N; Dopey, N-terminal
  13. XM_036160110.1XP_036016003.1  protein dopey-2 isoform X8

    Conserved Domains (2) summary
    pfam04118
    Location:1186
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:18692095
    Dopey_N; Dopey, N-terminal
  14. XM_030249266.2XP_030105126.1  protein dopey-2 isoform X10

    Conserved Domains (1) summary
    cl04407
    Location:16981924
    Dopey_N; Dopey, N-terminal
  15. XM_011246147.4XP_011244449.1  protein dopey-2 isoform X8

    Conserved Domains (2) summary
    pfam04118
    Location:1186
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:18692095
    Dopey_N; Dopey, N-terminal

RNA

  1. XR_876136.1 RNA Sequence

  2. XR_004939217.1 RNA Sequence

  3. XR_001781857.1 RNA Sequence

  4. XR_001781858.1 RNA Sequence

  5. XR_004939218.1 RNA Sequence

  6. XR_001781860.1 RNA Sequence

  7. XR_004939219.1 RNA Sequence

  8. XR_003951828.1 RNA Sequence

  9. XR_004939220.1 RNA Sequence

  10. XR_876139.2 RNA Sequence