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    ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 [ Homo sapiens (human) ]

    Gene ID: 9583, updated on 5-Mar-2024

    Summary

    Official Symbol
    ENTPD4provided by HGNC
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 4provided by HGNC
    Primary source
    HGNC:HGNC:14573
    See related
    Ensembl:ENSG00000197217 MIM:607577; AllianceGenome:HGNC:14573
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAP70; LALP70; LYSAL1; UDPase; NTPDase-4
    Summary
    This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in lymph node (RPKM 16.0), appendix (RPKM 14.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ENTPD4 in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (23429162..23457647, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (23704046..23732531, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (23286675..23315160, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23159094-23159594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23159595-23160095 Neighboring gene R3H domain and coiled-coil containing 1 Neighboring gene lysyl oxidase like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:23177410-23177975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23182003-23182503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23195830-23196330 Neighboring gene LOXL2 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:23209911-23210493 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23236632-23237224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23237225-23237815 Neighboring gene Sharpr-MPRA regulatory region 9444 Neighboring gene Sharpr-MPRA regulatory region 13358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23273382-23273902 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:23279735-23280235 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:23308148-23308855 Neighboring gene Sharpr-MPRA regulatory region 8456 Neighboring gene NANOG hESC enhancer GRCh37_chr8:23312327-23312828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19024 Neighboring gene ENTPD4 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23326741-23327240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:23339113-23340081 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 pseudogene Neighboring gene uncharacterized LOC105379327

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: LOXL2

    Clone Names

    • KIAA0392

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables CTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables UDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleoside diphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribonucleoside triphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in CTP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in CTP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in GDP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in UDP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in UDP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nucleobase-containing small molecule catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in autophagosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 4
    Names
    Golgi UDPase
    golgi luminal UDPase
    guanosine-diphosphatase like protein
    lysosomal apyrase-like 1
    lysosomal apyrase-like protein of 70 kDa
    uridine-diphosphatase
    NP_001122402.1
    NP_004892.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030021.1 RefSeqGene

      Range
      5085..33570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128930.3NP_001122402.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform b

      See identical proteins and their annotated locations for NP_001122402.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b, also known as LALP70v) is shorter than isoform a.
      Source sequence(s)
      AC104561, AF016032, DB091432, DC341200
      Consensus CDS
      CCDS47827.1
      UniProtKB/TrEMBL
      B4DU21
      Related
      ENSP00000408573.2, ENST00000417069.6
      Conserved Domains (1) summary
      cl17037
      Location:82532
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. NM_004901.5NP_004892.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform a

      See identical proteins and their annotated locations for NP_004892.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC104561, AJ131358, CN313713, CN313716, DC341200
      Consensus CDS
      CCDS6041.1
      UniProtKB/Swiss-Prot
      D3DSS3, O15092, Q9Y227
      UniProtKB/TrEMBL
      B4DU21
      Related
      ENSP00000351520.4, ENST00000358689.9
      Conserved Domains (1) summary
      cl17037
      Location:82540
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      23429162..23457647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      23704046..23732531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)