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    HTR3B 5-hydroxytryptamine receptor 3B [ Homo sapiens (human) ]

    Gene ID: 9177, updated on 11-Apr-2024

    Summary

    Official Symbol
    HTR3Bprovided by HGNC
    Official Full Name
    5-hydroxytryptamine receptor 3Bprovided by HGNC
    Primary source
    HGNC:HGNC:5298
    See related
    Ensembl:ENSG00000149305 MIM:604654; AllianceGenome:HGNC:5298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    5-HT3B
    Summary
    The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See HTR3B in Genome Data Viewer
    Location:
    11q23.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (113898923..113949079)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (113909263..113959423)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113775518..113819801)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 28 Neighboring gene RNA, U6 small nuclear 1107, pseudogene Neighboring gene U7 small nuclear RNA Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:113744182-113744682 Neighboring gene Sharpr-MPRA regulatory region 42 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5543 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:113746853-113747514 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:113752951-113753737 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:113756096-113756882 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:113766496-113766696 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:113813804-113813933 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:113822687-113823240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113827432-113828317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113835585-113836084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113845393-113846054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113846055-113846714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113859815-113860316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113860317-113860816 Neighboring gene uncharacterized LOC124902760 Neighboring gene 5-hydroxytryptamine receptor 3A Neighboring gene uncharacterized LOC124902759

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inorganic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in serotonin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of serotonin-activated cation-selective channel complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    part_of serotonin-activated cation-selective channel complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transmembrane transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 3B
    Names
    5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
    5-hydroxytryptamine 3 receptor B subunit
    serotonin-gated ion channel subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011483.2 RefSeqGene

      Range
      10875..55158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001363563.2NP_001350492.1  5-hydroxytryptamine receptor 3B isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP001874
      Consensus CDS
      CCDS86249.1
      Related
      ENSP00000443118.1, ENST00000537778.5
      Conserved Domains (1) summary
      cl27321
      Location:24424
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    2. NM_006028.5NP_006019.1  5-hydroxytryptamine receptor 3B isoform 1 precursor

      See identical proteins and their annotated locations for NP_006019.1

      Status: REVIEWED

      Source sequence(s)
      AP001874
      Consensus CDS
      CCDS8364.1
      UniProtKB/Swiss-Prot
      B0YJ23, O95264, Q0VJC3
      Related
      ENSP00000260191.2, ENST00000260191.8
      Conserved Domains (3) summary
      TIGR00860
      Location:8435
      LIC; Cation transporter family protein
      pfam02931
      Location:33239
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:246328
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      113898923..113949079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448767.2XP_024304535.1  5-hydroxytryptamine receptor 3B isoform X2

      Conserved Domains (1) summary
      cl27321
      Location:2337
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    2. XM_047427869.1XP_047283825.1  5-hydroxytryptamine receptor 3B isoform X3

    3. XM_017018552.3XP_016874041.1  5-hydroxytryptamine receptor 3B isoform X1

      Conserved Domains (2) summary
      pfam02931
      Location:2170
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:177259
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      113909263..113959423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370502.1XP_054226477.1  5-hydroxytryptamine receptor 3B isoform X2

    2. XM_054370503.1XP_054226478.1  5-hydroxytryptamine receptor 3B isoform X3

    3. XM_054370501.1XP_054226476.1  5-hydroxytryptamine receptor 3B isoform X1