Htr3b 5-hydroxytryptamine (serotonin) receptor 3B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htr3bprovided by MGI
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 3Bprovided by MGI
Primary source: MGI:MGI:1861899
See related: Ensembl:ENSMUSG00000008590 AllianceGenome:MGI:1861899
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5-HT3B
Summary: Enables serotonin-gated monoatomic cation channel activity. Predicted to be involved in several processes, including chemical synaptic transmission; inorganic cation transmembrane transport; and serotonin receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including adrenal gland; aorta-gonad-mesonephros; genitourinary system; gut; and nervous system. Human ortholog(s) of this gene implicated in alcohol use disorder and depressive disorder. Orthologous to human HTR3B (5-hydroxytryptamine receptor 3B). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 26.54 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (48846308..48876290, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (48935008..48964990, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It was concluded that epithelial 5-HT3 receptor may function as a mediator of gut microbiota-driven change in intestinal secretion.
Title: Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT(3) receptor expression via acetate production.
Results indicate that vestibular ganglion cells express functional 5-HT3 receptor channels (with 5-HT3a and 5-HT3b subunits) and might play a modulatory role in the peripheral vestibular nervous system
Title: 5-HT(3) receptor expression in the mouse vestibular ganglion.
Both serotonin and granisetron bind to an AA binding site in the heteromeric 5-HT3AB receptor.
Title: Agonists and antagonists bind to an A-A interface in the heteromeric 5-HT3AB receptor.
5-HT mediates enhanced neurogenic contractions of the mouse bladder muscle by an action at 5-HT(3) receptors. The presence of the 5-HT(3) receptor was confirmed by the expression of both 5-HT(3A) and 5-HT(3B) receptor subunits.
Title: Demonstration of 5-HT(3) receptor function and expression in the mouse bladder.
The 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells.(rat 5-Ht3B)
Title: Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells.
adaptive changes occur in the subunit composition of enteric 5-HT(3) receptors of 5-HT transporter -/- mice that are reflected in 5-HT(3) receptor affinity and desensitization
Title: Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables serotonin-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin-gated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables serotonin-gated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables serotonin-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in inorganic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in inorganic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in serotonin-gated cation-selective signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in serotonin-gated cation-selective signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of serotonin-activated cation-selective channel complex	IEA Inferred from Electronic Annotation more info
part_of serotonin-activated cation-selective channel complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 3B

Names: 5-HT3 receptor subunit B; 5-HT3-B; serotonin receptor 3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020274.4 → NP_064670.1 5-hydroxytryptamine receptor 3B precursor

See identical proteins and their annotated locations for NP_064670.1

Status: VALIDATED

Source sequence(s)

AK085213

Consensus CDS

CCDS23160.1

UniProtKB/Swiss-Prot

Q9JHJ5

Related

ENSMUSP00000008734.5, ENSMUST00000008734.5

Conserved Domains (3) summary

TIGR00860
Location:30 → 431

LIC; Cation transporter family protein

pfam02931
Location:30 → 233

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:242 → 313

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region