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    AQP10 aquaporin 10 [ Homo sapiens (human) ]

    Gene ID: 89872, updated on 6-Jun-2024

    Summary

    Official Symbol
    AQP10provided by HGNC
    Official Full Name
    aquaporin 10provided by HGNC
    Primary source
    HGNC:HGNC:16029
    See related
    Ensembl:ENSG00000143595 MIM:606578; AllianceGenome:HGNC:16029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AQPA_HUMAN
    Summary
    This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in duodenum (RPKM 31.0) and small intestine (RPKM 22.0) See more
    Orthologs
    NEW
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    Genomic context

    See AQP10 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (154321093..154325325)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (153458259..153462492)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154293569..154297801)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 239, pseudogene Neighboring gene RNA, U6 small nuclear 121, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:154293348-154293539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1776 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1777 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1355 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:154303097-154304296 Neighboring gene ATPase phospholipid transporting 8B2 Neighboring gene RNA, U7 small nuclear 57 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154320806-154321790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154321791-154322774 Neighboring gene MPRA-validated peak417 silencer Neighboring gene MPRA-validated peak418 silencer Neighboring gene mitochondrial ribosomal protein S33 pseudogene 1 Neighboring gene ribosomal protein SA pseudogene 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glycerol channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycerol channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables urea transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables water channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables water channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to acidic pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycerol transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycerol transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to toxic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in urea transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in water transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in water transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    aquaporin-10
    Names
    AQP-10
    aquaglyceroporin-10
    small intestine aquaporin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080429.3NP_536354.2  aquaporin-10

      See identical proteins and their annotated locations for NP_536354.2

      Status: REVIEWED

      Source sequence(s)
      AL162591, AL354980
      Consensus CDS
      CCDS1065.1
      UniProtKB/Swiss-Prot
      Q5VYD3, Q5VYD4, Q8NG70, Q96PS8
      UniProtKB/TrEMBL
      B2RC92
      Related
      ENSP00000318355.3, ENST00000324978.8
      Conserved Domains (1) summary
      cl00200
      Location:13265
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      154321093..154325325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510104.3XP_011508406.1  aquaporin-10 isoform X1

      UniProtKB/TrEMBL
      B2RC92
      Conserved Domains (1) summary
      cl00200
      Location:13266
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    2. XM_047433547.1XP_047289503.1  aquaporin-10 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      153458259..153462492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339481.1XP_054195456.1  aquaporin-10 isoform X1

      UniProtKB/TrEMBL
      B2RC92
    2. XM_054339482.1XP_054195457.1  aquaporin-10 isoform X2