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    EIF2B2 eukaryotic translation initiation factor 2B subunit beta [ Homo sapiens (human) ]

    Gene ID: 8892, updated on 9-Jun-2024

    Summary

    Official Symbol
    EIF2B2provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 2B subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:3258
    See related
    Ensembl:ENSG00000119718 MIM:606454; AllianceGenome:HGNC:3258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VWM2; EIF2B; EIF2Bbeta; EIF-2Bbeta
    Summary
    This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 32.7), adrenal (RPKM 18.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See EIF2B2 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (75002921..75012366)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (69212006..69221436)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75469624..75479069)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75388716-75389487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75389488-75390258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75401143-75401710 Neighboring gene uncharacterized LOC107984690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5938 Neighboring gene placental growth factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8733 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:75431938-75433137 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75446625-75447250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75447251-75447876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75447877-75448500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75469302-75469982 Neighboring gene RNA, U6 small nuclear 689, pseudogene Neighboring gene mutL homolog 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8735 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75535987-75536538 Neighboring gene acylphosphatase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoplasmic translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oligodendrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of translational initiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to glucose ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to heat TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to peptide hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of eukaryotic translation initiation factor 2B complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    translation initiation factor eIF2B subunit beta
    Names
    S20I15
    S20III15
    eIF-2B GDP-GTP exchange factor subunit beta
    eIF2B GDP-GTP exchange factor subunit beta
    eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
    translation initiation factor eIF-2B subunit beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013333.2 RefSeqGene

      Range
      5002..14447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014239.4NP_055054.1  translation initiation factor eIF2B subunit beta

      See identical proteins and their annotated locations for NP_055054.1

      Status: REVIEWED

      Source sequence(s)
      AI265790, AL049780, BC011750
      Consensus CDS
      CCDS9836.1
      UniProtKB/Swiss-Prot
      O43201, P49770
      UniProtKB/TrEMBL
      Q53XC2, Q9BPX4
      Related
      ENSP00000266126.5, ENST00000266126.10
      Conserved Domains (1) summary
      pfam01008
      Location:29333
      IF-2B; Initiation factor 2 subunit family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      75002921..75012366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      69212006..69221436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)