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Eif2b2 eukaryotic translation initiation factor 2B, subunit 2 beta [ Mus musculus (house mouse) ]

Gene ID: 217715, updated on 7-May-2024

Summary

Official Symbol
Eif2b2provided by MGI
Official Full Name
eukaryotic translation initiation factor 2B, subunit 2 betaprovided by MGI
Primary source
MGI:MGI:2145118
See related
Ensembl:ENSMUSG00000004788 AllianceGenome:MGI:2145118
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EIF2B; EIF-2Bbeta
Summary
This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. Mutations in the human gene are associated with ovarioleukodystrophy and leukoencephalopathy with vanishing white matter. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 35.6), thymus adult (RPKM 34.5) and 28 other tissues See more
Orthologs
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Genomic context

See Eif2b2 in Genome Data Viewer
Location:
12 D1; 12 39.6 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85266255..85273402)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85219481..85226628)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene placental growth factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86533825-86534109 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1858 Neighboring gene mutL homolog 3 Neighboring gene microRNA 6938 Neighboring gene 40S ribosomal protein S25 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic translational initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in oligodendrocyte development ISO
Inferred from Sequence Orthology
more info
 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 2B complex ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 2B complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in glycinergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
translation initiation factor eIF2B subunit beta
Names
eIF-2B GDP-GTP exchange factor subunit beta
eIF2B GDP-GTP exchange factor subunit beta
translation initiation factor eIF-2B subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145445.4NP_663420.1  translation initiation factor eIF2B subunit beta

    See identical proteins and their annotated locations for NP_663420.1

    Status: REVIEWED

    Source sequence(s)
    AC159237, AK049731
    Consensus CDS
    CCDS26053.1
    UniProtKB/Swiss-Prot
    Q99LD9
    UniProtKB/TrEMBL
    Q8BK57
    Related
    ENSMUSP00000004910.6, ENSMUST00000004910.12
    Conserved Domains (1) summary
    pfam01008
    Location:28333
    IF-2B; Initiation factor 2 subunit family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    85266255..85273402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)