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    H4C6 H4 clustered histone 6 [ Homo sapiens (human) ]

    Gene ID: 8361, updated on 17-Jun-2024

    Summary

    Official Symbol
    H4C6provided by HGNC
    Official Full Name
    H4 clustered histone 6provided by HGNC
    Primary source
    HGNC:HGNC:4783
    See related
    Ensembl:ENSG00000274618 MIM:602824; AllianceGenome:HGNC:4783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H4; H4/c; H4C1; H4C2; H4C3; H4C4; H4C5; H4C8; H4C9; H4FC; H4-16; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; HIST1H4F
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
    Orthologs
    NEW
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    Genomic context

    See H4C6 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26240393..26240793)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26108859..26109259)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26240621..26241021)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24216 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26234741-26235728 Neighboring gene H2A clustered histone 9, pseudogene Neighboring gene H1.3 linker histone, cluster member Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24219 Neighboring gene H4 clustered histone 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24222 Neighboring gene H3 clustered histone 7

    Genomic regions, transcripts, and products

    Bibliography

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H4
    Names
    H4 histone family, member C
    histone 1, H4f
    histone cluster 1 H4 family member f
    histone cluster 1, H4f

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003540.4NP_003531.1  histone H4

      See identical proteins and their annotated locations for NP_003531.1

      Status: REVIEWED

      Source sequence(s)
      AL031777
      Consensus CDS
      CCDS4598.1
      UniProtKB/Swiss-Prot
      A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
      UniProtKB/TrEMBL
      B2R4R0
      Related
      ENSP00000244537.6, ENST00000244537.6
      Conserved Domains (1) summary
      PLN00035
      Location:1103
      PLN00035; histone H4; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      26240393..26240793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      26108859..26109259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)