U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Plekha3 pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 [ Mus musculus (house mouse) ]

    Gene ID: 83435, updated on 5-Mar-2024

    Summary

    Official Symbol
    Plekha3provided by MGI
    Official Full Name
    pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3provided by MGI
    Primary source
    MGI:MGI:1932515
    See related
    Ensembl:ENSMUSG00000002733 AllianceGenome:MGI:1932515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FAPP1
    Summary
    Predicted to enable ceramide 1-phosphate transfer activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in ER to Golgi ceramide transport and intermembrane lipid transfer. Predicted to be located in Golgi apparatus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; orbito-sphenoid; and vascular system. Orthologous to human PLEKHA3 (pleckstrin homology domain containing A3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 43.1), bladder adult (RPKM 11.9) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Plekha3 in Genome Data Viewer
    Location:
    2 C3; 2 45.1 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76505436..76527679)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (76675305..76697335)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2624 Neighboring gene STARR-positive B cell enhancer ABC_E11139 Neighboring gene STARR-seq mESC enhancer starr_04894 Neighboring gene pejvakin Neighboring gene predicted gene, 39860 Neighboring gene FK506 binding protein 7 Neighboring gene predicted gene, 57692 Neighboring gene titin Neighboring gene STARR-seq mESC enhancer starr_04895 Neighboring gene coiled-coil domain containing 141 Neighboring gene STARR-seq mESC enhancer starr_04897 Neighboring gene STARR-seq mESC enhancer starr_04899 Neighboring gene STARR-seq mESC enhancer starr_04900 Neighboring gene STARR-seq mESC enhancer starr_04901 Neighboring gene predicted gene, 39861

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    pleckstrin homology domain-containing family A member 3
    Names
    FAPP-1
    PH domain-containing family A member 3
    phosphatidylinositol-four-phosphate adapter protein 1
    phosphoinositol 4-phosphate adapter protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031256.3NP_112546.1  pleckstrin homology domain-containing family A member 3

      See identical proteins and their annotated locations for NP_112546.1

      Status: VALIDATED

      Source sequence(s)
      AF286163, AL928789, BY730332
      Consensus CDS
      CCDS16162.1
      UniProtKB/Swiss-Prot
      Q9ERS4
      Related
      ENSMUSP00000107551.2, ENSMUST00000111920.2
      Conserved Domains (1) summary
      cd01247
      Location:1100
      PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      76505436..76527679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500446.5XP_006500509.1  pleckstrin homology domain-containing family A member 3 isoform X1

      See identical proteins and their annotated locations for XP_006500509.1

      UniProtKB/Swiss-Prot
      Q9ERS4
      Conserved Domains (1) summary
      cd01247
      Location:1100
      PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain