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    Plekha3 pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 [ Mus musculus (house mouse) ]

    Gene ID: 83435, updated on 23-Jun-2021

    Summary

    Official Symbol
    Plekha3provided by MGI
    Official Full Name
    pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3provided by MGI
    Primary source
    MGI:MGI:1932515
    See related
    Ensembl:ENSMUSG00000002733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FA; FAPP1
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 43.1), bladder adult (RPKM 11.9) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Plekha3 in Genome Data Viewer
    Location:
    2; 2 C3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76505436..76527679)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (76675305..76697335)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (76513372..76535392)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene pejvakin Neighboring gene predicted gene, 39860 Neighboring gene FK506 binding protein 7 Neighboring gene titin Neighboring gene coiled-coil domain containing 141 Neighboring gene predicted gene, 39861

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ceramide 1-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ceramide 1-phosphate transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ER to Golgi ceramide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ceramide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intermembrane lipid transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    pleckstrin homology domain-containing family A member 3
    Names
    FAPP-1
    PH domain-containing family A member 3
    phosphatidylinositol-four-phosphate adapter protein 1
    phosphoinositol 4-phosphate adapter protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031256.3NP_112546.1  pleckstrin homology domain-containing family A member 3

      See identical proteins and their annotated locations for NP_112546.1

      Status: VALIDATED

      Source sequence(s)
      AF286163, AL928789, BY730332
      Consensus CDS
      CCDS16162.1
      UniProtKB/Swiss-Prot
      Q9ERS4
      Related
      ENSMUSP00000107551.2, ENSMUST00000111920.2
      Conserved Domains (1) summary
      cd01247
      Location:1100
      PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      76505436..76527679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500446.5XP_006500509.1  pleckstrin homology domain-containing family A member 3 isoform X1

      See identical proteins and their annotated locations for XP_006500509.1

      UniProtKB/Swiss-Prot
      Q9ERS4
      Conserved Domains (1) summary
      cd01247
      Location:1100
      PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain
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