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PLEKHA3 pleckstrin homology domain containing A3 [ Homo sapiens (human) ]

Gene ID: 65977, updated on 5-Aug-2022

Summary

Official Symbol
PLEKHA3provided by HGNC
Official Full Name
pleckstrin homology domain containing A3provided by HGNC
Primary source
HGNC:HGNC:14338
See related
Ensembl:ENSG00000116095 MIM:607774; AllianceGenome:HGNC:14338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAPP1
Summary
Enables identical protein binding activity and phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in ceramide transport and intermembrane lipid transfer. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.6), adrenal (RPKM 2.0) and 25 other tissues See more
Orthologs
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Genomic context

See PLEKHA3 in Genome Data Viewer
Location:
2q31.2
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (178480457..178516463)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (178963251..178999257)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (179345184..179381190)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124906102 Neighboring gene uncharacterized LOC124907911 Neighboring gene nuclear distribution C pseudogene 2 Neighboring gene pejvakin Neighboring gene FKBP prolyl isomerase 7 Neighboring gene TTN antisense RNA 1 Neighboring gene titin Neighboring gene uncharacterized LOC124906100 Neighboring gene uncharacterized LOC124907912

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of pleckstrin homology domain containing, family A, member 3 (PLEKHA3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20067

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ceramide 1-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ceramide 1-phosphate transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in ceramide 1-phosphate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ceramide transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intermembrane lipid transfer IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pleckstrin homology domain-containing family A member 3
Names
FAPP-1
PH domain-containing family A member 3
four-phosphate-adaptor protein 1
phosphatidylinositol-four-phosphate adapter protein 1
phosphoinositol 4-phosphate adapter protein 1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019091.4NP_061964.3  pleckstrin homology domain-containing family A member 3

    See identical proteins and their annotated locations for NP_061964.3

    Status: VALIDATED

    Source sequence(s)
    AC009948, AK074209, BC039812, BM794932
    Consensus CDS
    CCDS33336.1
    UniProtKB/Swiss-Prot
    Q9HB20, Q9NXT3
    Related
    ENSP00000234453.4, ENST00000234453.10
    Conserved Domains (1) summary
    cd01247
    Location:1100
    PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    178480457..178516463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445577.1XP_047301533.1  pleckstrin homology domain-containing family A member 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    178963251..178999257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)