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    Trim23 tripartite motif-containing 23 [ Mus musculus (house mouse) ]

    Gene ID: 81003, updated on 20-Jul-2021

    Summary

    Official Symbol
    Trim23provided by MGI
    Official Full Name
    tripartite motif-containing 23provided by MGI
    Primary source
    MGI:MGI:1933161
    See related
    Ensembl:ENSMUSG00000021712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arf; Arfd1; AI450195; 6330516O20Rik
    Expression
    Broad expression in CNS E18 (RPKM 7.0), frontal lobe adult (RPKM 5.5) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Trim23 in Genome Data Viewer
    Location:
    13; 13 D1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (104315187..104339983)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (104178839..104203475)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (104969178..104992128)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta Neighboring gene trafficking protein particle complex 13 Neighboring gene shieldin complex subunit 3 Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene centromere protein K Neighboring gene a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6 Neighboring gene predicted gene 8680

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM23
    Names
    ADP-ribosylation factor domain protein 1, 64kD
    ADP-ribosylation factor domain-containing protein 1
    GTP-binding protein ARD-1
    RING-type E3 ubiquitin transferase TRIM23
    tripartite motif protein TRIM23
    tripartite motif-containing protein 23
    NP_001348467.1
    NP_001348468.1
    XP_036014122.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361538.1NP_001348467.1  E3 ubiquitin-protein ligase TRIM23 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154216, AK039280
      Consensus CDS
      CCDS88515.1
      Related
      ENSMUSP00000022225.6, ENSMUST00000022225.12
      Conserved Domains (5) summary
      smart00336
      Location:173219
      BBOX; B-Box-type zinc finger
      cd04158
      Location:406574
      ARD1; (ADP-ribosylation factor domain protein 1 (ARD1)
      cd00021
      Location:125168
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd16645
      Location:2877
      mRING-HC-C3HC3D_TRIM23_C-IX; Modified RING finger, HC subclass (C3HC3D-type), found in tripartite motif-containing protein 23 (TRIM23) and similar proteins
      cl25407
      Location:226370
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    2. NM_001361539.1NP_001348468.1  E3 ubiquitin-protein ligase TRIM23 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154216
      Consensus CDS
      CCDS88516.1
      Related
      ENSMUSP00000070767.6, ENSMUST00000069187.12
      Conserved Domains (5) summary
      smart00336
      Location:173216
      BBOX; B-Box-type zinc finger
      cd04158
      Location:345513
      ARD1; (ADP-ribosylation factor domain protein 1 (ARD1)
      cd00021
      Location:125168
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd16645
      Location:2877
      mRING-HC-C3HC3D_TRIM23_C-IX; Modified RING finger, HC subclass (C3HC3D-type), found in tripartite motif-containing protein 23 (TRIM23) and similar proteins
      cl25407
      Location:214309
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      104315187..104339983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158229.1XP_036014122.1  E3 ubiquitin-protein ligase TRIM23 isoform X1

      Conserved Domains (5) summary
      smart00502
      Location:259403
      BBC; B-Box C-terminal domain
      cd16645
      Location:61110
      mRING-HC-C3HC3D_TRIM23_C-IX; Modified RING finger, HC subclass (C3HC3D-type), found in tripartite motif-containing protein 23 (TRIM23) and similar proteins
      cd19773
      Location:156205
      Bbox2_TRIM23_C-IX_rpt1; first B-box-type 2 zinc finger found in tripartite motif-containing protein 23 (TRIM23) and similar proteins
      cd19774
      Location:207256
      Bbox2_TRIM23_C-IX_rpt2; second B-box-type 2 zinc finger found in tripartite motif-containing protein 23 (TRIM23) and similar proteins
      cl38936
      Location:424510
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_030731.3: Suppressed sequence

      Description
      NM_030731.3: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
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