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    Brpf1 bromodomain and PHD finger containing, 1 [ Mus musculus (house mouse) ]

    Gene ID: 78783, updated on 31-Jan-2019

    Summary

    Official Symbol
    Brpf1provided by MGI
    Official Full Name
    bromodomain and PHD finger containing, 1provided by MGI
    Primary source
    MGI:MGI:1926033
    See related
    Ensembl:ENSMUSG00000001632
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brpf2; 4833438B11Rik; 4930540D11Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 16.2), CNS E11.5 (RPKM 12.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Brpf1 in Genome Data Viewer
    Location:
    6; 6 E3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (113306787..113324862)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (113257191..113274703)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 14 Neighboring gene copine family member IX Neighboring gene 8-oxoguanine DNA-glycosylase 1 Neighboring gene calcium/calmodulin-dependent protein kinase I Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • 4833438B11Rik, 4930540D11Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to histone acetyltransferase activity (H3-K23 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    common myeloid progenitor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-K23 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3-K23 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peregrin
    Names
    bromodomain and PHD finger-containing protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282126.1NP_001269055.1  peregrin isoform 1

      See identical proteins and their annotated locations for NP_001269055.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC155287, AK019522, AK043372, BC046521, BY469507
      Consensus CDS
      CCDS71809.1
      UniProtKB/TrEMBL
      Q3U109, Q80XK2, Q8C905, Q9CTY1
      Related
      ENSMUSP00000108744.1, ENSMUST00000113119.7
      Conserved Domains (5) summary
      cd05839
      Location:11161231
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:631728
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15676
      Location:266327
      PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      cd15701
      Location:329449
      ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      pfam10513
      Location:106254
      EPL1; Enhancer of polycomb-like
    2. NM_001282127.1NP_001269056.1  peregrin isoform 3

      See identical proteins and their annotated locations for NP_001269056.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AK019522, AK043372, BC046521, BY469507
      Consensus CDS
      CCDS71810.1
      UniProtKB/Swiss-Prot
      B2RRD7
      UniProtKB/TrEMBL
      Q80XK2, Q8C905, Q9CTY1
      Conserved Domains (5) summary
      cd05839
      Location:10811196
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:631728
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5189
      Location:2050
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      cd15701
      Location:329449
      ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      cl26518
      Location:173656
      EPL1; Enhancer of polycomb-like
    3. NM_001282128.1NP_001269057.1  peregrin isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site, and lacks an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
      Source sequence(s)
      AC155287, AK019522, AK043372, BC046521, BY469507
      Consensus CDS
      CCDS85115.1
      UniProtKB/TrEMBL
      A0A0N4SVG7, Q80XK2, Q8C905, Q9CTY1
      Related
      ENSMUSP00000145093.1, ENSMUST00000204626.2
      Conserved Domains (5) summary
      cd05839
      Location:10871202
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:631734
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15676
      Location:266327
      PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      cd15701
      Location:329449
      ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      pfam10513
      Location:106254
      EPL1; Enhancer of polycomb-like
    4. NM_030178.2NP_084454.1  peregrin isoform 2

      See identical proteins and their annotated locations for NP_084454.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK019522, AK043372, BC046521, BY469507
      Consensus CDS
      CCDS39592.1
      UniProtKB/TrEMBL
      Q80XK2, Q8C905, Q9CTY1
      Related
      ENSMUSP00000108742.1, ENSMUST00000113117.3
      Conserved Domains (5) summary
      cd05839
      Location:11151230
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:631728
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15676
      Location:266327
      PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      cd15701
      Location:329449
      ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      pfam10513
      Location:106254
      EPL1; Enhancer of polycomb-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      113306787..113324862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321837.1XP_017177326.1  peregrin isoform X7

    2. XM_017321838.1XP_017177327.1  peregrin isoform X8

    3. XM_017321839.1XP_017177328.1  peregrin isoform X9

      UniProtKB/TrEMBL
      A0A0N4SUS4
      Related
      ENSMUSP00000144804.1, ENSMUST00000204198.2
    4. XM_006506783.3XP_006506846.1  peregrin isoform X1

      See identical proteins and their annotated locations for XP_006506846.1

      Conserved Domains (5) summary
      cd05839
      Location:11221237
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:631734
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15676
      Location:266327
      PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      cd15701
      Location:329449
      ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      pfam10513
      Location:106254
      EPL1; Enhancer of polycomb-like
    5. XM_006506782.3XP_006506845.1  peregrin isoform X1

      See identical proteins and their annotated locations for XP_006506845.1

      Conserved Domains (5) summary
      cd05839
      Location:11221237
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:631734
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15676
      Location:266327
      PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      cd15701
      Location:329449
      ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      pfam10513
      Location:106254
      EPL1; Enhancer of polycomb-like
    6. XM_006506786.3XP_006506849.1  peregrin isoform X4

      UniProtKB/TrEMBL
      E9PXP1
      Related
      ENSMUSP00000108746.2, ENSMUST00000113121.7
      Conserved Domains (5) summary
      cd05839
      Location:10881203
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:631734
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15676
      Location:266327
      PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      cd15701
      Location:329449
      ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      pfam10513
      Location:106254
      EPL1; Enhancer of polycomb-like
    7. XM_006506784.3XP_006506847.1  peregrin isoform X2

      UniProtKB/TrEMBL
      A0A0N4SUT9
      Related
      ENSMUSP00000144820.1, ENSMUST00000203577.1
      Conserved Domains (5) summary
      cd05839
      Location:11211236
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:631734
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15676
      Location:266327
      PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      cd15701
      Location:329449
      ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      pfam10513
      Location:106254
      EPL1; Enhancer of polycomb-like
    8. XM_006506785.3XP_006506848.1  peregrin isoform X3

      See identical proteins and their annotated locations for XP_006506848.1

      UniProtKB/TrEMBL
      Q80XK2
      Conserved Domains (5) summary
      cd05839
      Location:11151230
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:631728
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15676
      Location:266327
      PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      cd15701
      Location:329449
      ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      pfam10513
      Location:106254
      EPL1; Enhancer of polycomb-like
    9. XM_006506787.3XP_006506850.1  peregrin isoform X5

      Conserved Domains (5) summary
      cd05839
      Location:10821197
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:631728
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15676
      Location:266327
      PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      cd15701
      Location:329449
      ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      pfam10513
      Location:106254
      EPL1; Enhancer of polycomb-like
    10. XM_006506788.3XP_006506851.1  peregrin isoform X6

      See identical proteins and their annotated locations for XP_006506851.1

      UniProtKB/Swiss-Prot
      B2RRD7
      Related
      ENSMUSP00000108747.1, ENSMUST00000113122.7
      Conserved Domains (5) summary
      cd05839
      Location:10811196
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:631728
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5189
      Location:2050
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      cd15701
      Location:329449
      ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
      cl26518
      Location:173656
      EPL1; Enhancer of polycomb-like
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