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BRPF1 bromodomain and PHD finger containing 1 [ Homo sapiens (human) ]

Gene ID: 7862, updated on 9-Feb-2020

Summary

Official Symbol
BRPF1provided by HGNC
Official Full Name
bromodomain and PHD finger containing 1provided by HGNC
Primary source
HGNC:HGNC:14255
See related
Ensembl:ENSG00000156983 MIM:602410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BR140; IDDDFP
Summary
This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in testis (RPKM 10.0), bone marrow (RPKM 8.9) and 25 other tissues See more
Orthologs

Genomic context

See BRPF1 in Genome Data Viewer
Location:
3p25.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (9731729..9748015)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9773413..9789699)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 14 Neighboring gene copine family member 9 Neighboring gene 8-oxoguanine DNA glycosylase Neighboring gene calcium/calmodulin dependent protein kinase I Neighboring gene ARPC4-TTLL3 readthrough Neighboring gene transcriptional adaptor 3 Neighboring gene actin related protein 2/3 complex subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates bromodomain and PHD finger-containing protein 1 (BRPF1) in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to histone acetyltransferase activity (H3-K23 specific) IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-K23 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
MOZ/MORF histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
peregrin
Names
bromodomain-containing protein, 140kD

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052955.1 RefSeqGene

    Range
    5007..21287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001003694.2NP_001003694.1  peregrin isoform 1

    See identical proteins and their annotated locations for NP_001003694.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI356310, AK293865, BC053851
    Consensus CDS
    CCDS33692.1
    UniProtKB/Swiss-Prot
    P55201
    Related
    ENSP00000373340.2, ENST00000383829.7
    Conserved Domains (6) summary
    cd05839
    Location:10891204
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:632735
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15676
    Location:267328
    PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    cd15701
    Location:330450
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    pfam10513
    Location:106255
    EPL1; Enhancer of polycomb-like
    cl10717
    Location:1552
    CactinC_cactus; Cactus-binding C-terminus of cactin protein
  2. NM_001319049.1NP_001305978.1  peregrin isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks an exon compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC022382, AK293865, BC068262
    Consensus CDS
    CCDS82729.1
    UniProtKB/Swiss-Prot
    P55201
    Related
    ENSP00000402485.2, ENST00000433861.6
    Conserved Domains (6) summary
    cd05839
    Location:9881103
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:632729
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15676
    Location:267328
    PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    cd15701
    Location:330450
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    pfam10513
    Location:106255
    EPL1; Enhancer of polycomb-like
    cl10717
    Location:1552
    CactinC_cactus; Cactus-binding C-terminus of cactin protein
  3. NM_001319050.1NP_001305979.1  peregrin isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC022382, AL713696, BC068262
    Consensus CDS
    CCDS82730.1
    UniProtKB/Swiss-Prot
    P55201
    Related
    ENSP00000398863.1, ENST00000424362.6
    Conserved Domains (6) summary
    cd05839
    Location:10821197
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:632729
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15676
    Location:267328
    PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    cd15701
    Location:330450
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    pfam10513
    Location:106255
    EPL1; Enhancer of polycomb-like
    cl10717
    Location:1552
    CactinC_cactus; Cactus-binding C-terminus of cactin protein
  4. NM_004634.2NP_004625.2  peregrin isoform 2

    See identical proteins and their annotated locations for NP_004625.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, as compared to variant 1. The encoded isoform 2 is thus shorter than isoform 1.
    Source sequence(s)
    AI356310, BC036374, BC053851
    Consensus CDS
    CCDS2575.1
    UniProtKB/Swiss-Prot
    P55201
    Related
    ENSP00000410210.1, ENST00000457855.1
    Conserved Domains (6) summary
    cd05839
    Location:10831198
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:632729
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15676
    Location:267328
    PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    cd15701
    Location:330450
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    pfam10513
    Location:106255
    EPL1; Enhancer of polycomb-like
    cl10717
    Location:1552
    CactinC_cactus; Cactus-binding C-terminus of cactin protein

RNA

  1. NR_160918.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022382
    Related
    ENST00000673551.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    9731729..9748015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453741.1XP_024309509.1  peregrin isoform X1

    Conserved Domains (5) summary
    cd05839
    Location:11231238
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:632735
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5189
    Location:2052
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:330450
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    cl26518
    Location:174657
    EPL1; Enhancer of polycomb-like
  2. XM_024453744.1XP_024309512.1  peregrin isoform X6

    Conserved Domains (5) summary
    cd05839
    Location:10281143
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:632735
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5189
    Location:2052
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:330450
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    cl26518
    Location:174657
    EPL1; Enhancer of polycomb-like
  3. XM_024453743.1XP_024309511.1  peregrin isoform X2

    Conserved Domains (5) summary
    cd05839
    Location:11221237
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:632735
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5189
    Location:2052
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:330450
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    cl26518
    Location:174657
    EPL1; Enhancer of polycomb-like
  4. XM_005265450.1XP_005265507.1  peregrin isoform X5

    See identical proteins and their annotated locations for XP_005265507.1

    Conserved Domains (6) summary
    cd05839
    Location:10881203
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:632735
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15676
    Location:267328
    PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    cd15701
    Location:330450
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    pfam10513
    Location:106255
    EPL1; Enhancer of polycomb-like
    cl10717
    Location:1552
    CactinC_cactus; Cactus-binding C-terminus of cactin protein
  5. XM_011534101.1XP_011532403.1  peregrin isoform X3

    See identical proteins and their annotated locations for XP_011532403.1

    Related
    ENSP00000499951.1, ENST00000672515.1
    Conserved Domains (6) summary
    cd05839
    Location:11171232
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:632729
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15676
    Location:267328
    PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    cd15701
    Location:330450
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    pfam10513
    Location:106255
    EPL1; Enhancer of polycomb-like
    cl10717
    Location:1552
    CactinC_cactus; Cactus-binding C-terminus of cactin protein
  6. XM_005265449.1XP_005265506.1  peregrin isoform X4

    See identical proteins and their annotated locations for XP_005265506.1

    Conserved Domains (6) summary
    cd05839
    Location:11161231
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:632729
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15676
    Location:267328
    PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    cd15701
    Location:330450
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    pfam10513
    Location:106255
    EPL1; Enhancer of polycomb-like
    cl10717
    Location:1552
    CactinC_cactus; Cactus-binding C-terminus of cactin protein
  7. XM_024453742.1XP_024309510.1  peregrin isoform X1

    Conserved Domains (5) summary
    cd05839
    Location:11231238
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:632735
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5189
    Location:2052
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:330450
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
    cl26518
    Location:174657
    EPL1; Enhancer of polycomb-like

RNA

  1. XR_001740257.1 RNA Sequence

    Related
    ENST00000672126.1
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