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    Mvp major vault protein [ Mus musculus (house mouse) ]

    Gene ID: 78388, updated on 3-Apr-2024


    Official Symbol
    Mvpprovided by MGI
    Official Full Name
    major vault proteinprovided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000030681 AllianceGenome:MGI:1925638
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LRP; VAULT1; 2310009M24Rik
    Predicted to enable identical protein binding activity; protein kinase binding activity; and protein phosphatase binding activity. Involved in cell population proliferation and protein activation cascade. Predicted to be located in cytoskeleton; cytosol; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in cranial ganglion; gut; and skeleton. Human ortholog(s) of this gene implicated in mitral valve prolapse. Orthologous to human MVP (major vault protein). [provided by Alliance of Genome Resources, Apr 2022]
    Broad expression in colon adult (RPKM 103.4), large intestine adult (RPKM 83.6) and 16 other tissues See more
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    Genomic context

    See Mvp in Genome Data Viewer
    7 F3; 7 69.26 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126586036..126613729, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126986860..127014594, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134119536-134119823 Neighboring gene CDIP transferase, opposite strand Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase Neighboring gene STARR-seq mESC enhancer starr_20161 Neighboring gene STARR-positive B cell enhancer ABC_E2850 Neighboring gene PAXIP1 associated glutamate rich protein 1A Neighboring gene proline-rich transmembrane protein 2 Neighboring gene predicted gene, 53372

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080638.4NP_542369.3  major vault protein

      Status: VALIDATED

      Source sequence(s)
      Consensus CDS
      Q922X6, Q9EQK5
      ENSMUSP00000127250.3, ENSMUST00000165096.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000073.7 Reference GRCm39 C57BL/6J

      126586036..126613729 complement
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241952.3XP_011240254.1  major vault protein isoform X1

      See identical proteins and their annotated locations for XP_011240254.1

      Q922X6, Q9EQK5
      Conserved Domains (1) summary
      PTZ00491; major vault protein; Provisional