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MVP major vault protein [ Homo sapiens (human) ]

Gene ID: 9961, updated on 23-Dec-2018

Summary

Official Symbol
MVPprovided by HGNC
Official Full Name
major vault proteinprovided by HGNC
Primary source
HGNC:HGNC:7531
See related
Ensembl:ENSG00000013364 MIM:605088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRP; VAULT1
Summary
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in colon (RPKM 85.5), small intestine (RPKM 74.9) and 25 other tissues See more
Orthologs

Genomic context

See MVP in Genome Data Viewer
Location:
16p11.2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (29820394..29848039)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29831715..29859360)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268170 Neighboring gene MYC associated zinc finger protein Neighboring gene proline rich transmembrane protein 2 Neighboring gene PAXIP1 associated glutamate rich protein 1 Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase Neighboring gene CDIP transferase opposite strand, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ERBB signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of signaling IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nuclear pore IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
major vault protein
Names
lung resistance-related protein
testicular secretory protein Li 30

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293204.1NP_001280133.1  major vault protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate in-frame splice junction in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AJ291366, BM999583, KJ534886
    UniProtKB/Swiss-Prot
    Q14764
    UniProtKB/TrEMBL
    X5DNU0
    Conserved Domains (3) summary
    PTZ00491
    Location:4790
    PTZ00491; major vault protein; Provisional
    cd08825
    Location:509670
    MVP_shoulder; Shoulder domain of the major vault protein
    pfam01505
    Location:114153
    Vault; Major Vault Protein repeat
  2. NM_001293205.1NP_001280134.1  major vault protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the central coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AJ291366, BC015623, BM999583, KJ534885
    UniProtKB/Swiss-Prot
    Q14764
    UniProtKB/TrEMBL
    X5D7K9
    Conserved Domains (3) summary
    PTZ00491
    Location:4784
    PTZ00491; major vault protein; Provisional
    pfam01505
    Location:114153
    Vault; Major Vault Protein repeat
    cl19107
    Location:480604
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
  3. NM_005115.5NP_005106.2  major vault protein isoform 1

    See identical proteins and their annotated locations for NP_005106.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as S-MVP) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform 1.
    Source sequence(s)
    BC015623, BM999583, BQ932800, DA940597
    Consensus CDS
    CCDS10656.1
    UniProtKB/Swiss-Prot
    Q14764
    UniProtKB/TrEMBL
    X5D2M8
    Related
    ENSP00000349977.5, ENST00000357402.9
    Conserved Domains (1) summary
    cl27548
    Location:4850
    Vault; Major Vault Protein repeat
  4. NM_017458.3NP_059447.2  major vault protein isoform 1

    See identical proteins and their annotated locations for NP_059447.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as L-MVP) is the longest transcript. Variants 1 and 2 encode the same isoform 1.
    Source sequence(s)
    BC008932, BM999583, BU151678, DA842337
    Consensus CDS
    CCDS10656.1
    UniProtKB/Swiss-Prot
    Q14764
    UniProtKB/TrEMBL
    X5D2M8
    Related
    ENSP00000378760.1, ENST00000395353.5
    Conserved Domains (1) summary
    cl27548
    Location:4850
    Vault; Major Vault Protein repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    29820394..29848039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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