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    Sun1 Sad1 and UNC84 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 77053, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sun1provided by MGI
    Official Full Name
    Sad1 and UNC84 domain containing 1provided by MGI
    Primary source
    MGI:MGI:1924303
    See related
    Ensembl:ENSMUSG00000036817 AllianceGenome:MGI:1924303
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Unc84a; mKIAA0810; 4632417G13Rik; 5730434D03Rik
    Summary
    Enables lamin binding activity. Involved in centrosome localization; meiotic attachment of telomere to nuclear envelope; and nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration. Acts upstream of or within homologous chromosome pairing at meiosis. Located in chromosome, telomeric region; cytoplasm; and nuclear inner membrane. Is expressed in epidermis; intercostal muscle; spermatocyte; and spermatozoon. Orthologous to human SUN1 (Sad1 and UNC84 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 24.4), bladder adult (RPKM 22.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sun1 in Genome Data Viewer
    Location:
    5 G2; 5 78.12 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139186313..139235594)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139200564..139249839)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330403L08 gene Neighboring gene platelet derived growth factor, alpha Neighboring gene protein kinase, cAMP dependent regulatory, type I beta Neighboring gene STARR-positive B cell enhancer ABC_E1695 Neighboring gene STARR-seq mESC enhancer starr_14685 Neighboring gene STARR-positive B cell enhancer ABC_E10360 Neighboring gene dynein, axonemal assembly factor 5 Neighboring gene STARR-seq mESC enhancer starr_14686 Neighboring gene STARR-seq mESC enhancer starr_14687 Neighboring gene STARR-positive B cell enhancer ABC_E4802 Neighboring gene golgi to ER traffic protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E2770 Neighboring gene STARR-positive B cell enhancer ABC_E6389 Neighboring gene STARR-positive B cell enhancer ABC_E9266 Neighboring gene ArfGAP with dual PH domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E8825

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. Ding X, et al. Dev Cell, 2007 Jun. PMID 17543860
    2. Sun1 forms immobile macromolecular assemblies at the nuclear envelope. Lu W, et al. Biochim Biophys Acta, 2008 Dec. PMID 18845190
    3. Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation. Buglak DB, et al. Elife, 2023 Mar 29. PMID 36989130, Free PMC Article
    4. Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA. Chi YH, et al. Development, 2009 Mar. PMID 19211677, Free PMC Article
    5. Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. Lei K, et al. Curr Biol, 2012 Sep 11. PMID 22863315, Free PMC Article

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation.
      Title: Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation.
    2. The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
      Title: The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
    3. Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy.
      Title: Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy.
    4. The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
      Title: The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
    5. SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
      Title: SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
    6. Comparison of the miRNA profiles between wildtype and SUN1 null myotubes identified a cluster of miRNAs encoded by a non-translated retrotransposon-like one antisense (Rtl1as) transcript that are decreased in the WT myoblasts due to SUN1 inhibition of Drosha
      Title: The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity.
    7. Results provide evidence that SUN1 and KASH5 are essential factors in the regulation of meiotic resumption and spindle formation.
      Title: Depletion of the LINC complex disrupts cytoskeleton dynamics and meiotic resumption in mouse oocytes.
    8. A cell-type-specific role for Sun1 and Sun2 in nucleokinesis during cerebellar development, is reported.
      Title: Sun1 deficiency leads to cerebellar ataxia in mice.
    9. ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome.
      Title: CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase.
    10. our results clearly indicate that SUN1 and SUN2, at least partially, fulfill redundant meiotic functions
      Title: Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0810

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytoskeleton-nuclear membrane anchor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lamin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic attachment of telomere to nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nuclear envelope organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear matrix anchoring at nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear matrix anchoring at nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope TAS
    Traceable Author Statement
    more info
    		  
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SUN domain-containing protein 1
    Names
    protein unc-84 homolog A
    sad1/unc-84 protein-like 1
    unc-84 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256115.1 → NP_001243044.1  SUN domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001243044.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK036187, AV239459, CK389844
      Consensus CDS
      CCDS57395.1
      UniProtKB/Swiss-Prot
      Q9D666
      Related
      ENSMUSP00000106508.3, ENSMUST00000110884.9
      Conserved Domains (2) summary
      pfam07738
      Location:740 → 874
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:73 → 378
      MRP; Mitochondrial RNA binding protein MRP

    2. NM_001256116.2 → NP_001243045.1  SUN domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC125065
      Consensus CDS
      CCDS57396.1
      UniProtKB/Swiss-Prot
      Q9D666
      Related
      ENSMUSP00000077756.7, ENSMUST00000078690.13
      Conserved Domains (2) summary
      pfam07738
      Location:713 → 847
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:73 → 351
      MRP; Mitochondrial RNA binding protein MRP

    3. NM_001256117.1 → NP_001243046.1  SUN domain-containing protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001243046.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three consecutive exons in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (4) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK014585, AV239459, CK389844
      Consensus CDS
      CCDS57397.1
      UniProtKB/Swiss-Prot
      Q9D666
      Related
      ENSMUSP00000106507.3, ENSMUST00000110883.9
      Conserved Domains (2) summary
      pfam07738
      Location:654 → 788
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:73 → 292
      MRP; Mitochondrial RNA binding protein MRP

    4. NM_001256118.1 → NP_001243047.1  SUN domain-containing protein 1 isoform 5

      See identical proteins and their annotated locations for NP_001243047.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks four consecutive exons in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (5) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK160281, BQ551727, HQ402597
      Consensus CDS
      CCDS57398.1
      UniProtKB/Swiss-Prot
      Q9D666
      Related
      ENSMUSP00000106506.2, ENSMUST00000110882.8
      Conserved Domains (2) summary
      pfam07738
      Location:621 → 755
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:73 → 259
      MRP; Mitochondrial RNA binding protein MRP

    5. NM_001359494.1 → NP_001346423.1  SUN domain-containing protein 1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an in-frame exon in the coding region and uses an alternate in-frame splice junction, compared to variant 1. The resulting isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AC125065
      Conserved Domains (3) summary
      pfam07738
      Location:712 → 846
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:73 → 351
      MRP; Mitochondrial RNA binding protein MRP
      cl25732
      Location:428 → 579
      SMC_N; RecF/RecN/SMC N terminal domain

    6. NM_001359496.1 → NP_001346425.1  SUN domain-containing protein 1 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks two alternate in-frame exons, compared to variant 1. The resulting isoform (7) is shorter than isoform 1.
      Source sequence(s)
      AC125065
      Conserved Domains (3) summary
      pfam07738
      Location:676 → 810
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:73 → 314
      MRP; Mitochondrial RNA binding protein MRP
      cl25732
      Location:385 → 564
      SMC_N; RecF/RecN/SMC N terminal domain

    7. NM_024451.2 → NP_077771.1  SUN domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_077771.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK160281, AK167686, BY036585
      Consensus CDS
      CCDS19804.1
      UniProtKB/Swiss-Prot
      D3Z0V9, Q3TIW3, Q3TV96, Q6B4H0, Q80SU8, Q8BZ99, Q99P23, Q9D666
      Related
      ENSMUSP00000056655.8, ENSMUST00000058716.14
      Conserved Domains (5) summary
      COG1196
      Location:486 → 665
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:777 → 911
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:63 → 415
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:709 → 734
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21439
      Location:553 → 606
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      139186313..139235594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165598.1 → XP_036021491.1  SUN domain-containing protein 1 isoform X22

      UniProtKB/TrEMBL
      Q3TSM1
      Related
      ENSMUSP00000098086.4, ENSMUST00000100517.10
      Conserved Domains (1) summary
      pfam09387
      Location:92 → 253
      MRP; Mitochondrial RNA binding protein MRP

    2. XM_017321156.3 → XP_017176645.1  SUN domain-containing protein 1 isoform X1

      Conserved Domains (4) summary
      pfam07738
      Location:815 → 949
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:543 → 706
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 259
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:747 → 772
      Sun2_CC2; SUN2 coiled coil domain 2

    3. XM_017321157.3 → XP_017176646.1  SUN domain-containing protein 1 isoform X2

      Conserved Domains (4) summary
      pfam07738
      Location:814 → 948
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:543 → 705
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 259
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:746 → 771
      Sun2_CC2; SUN2 coiled coil domain 2

    4. XM_036165596.1 → XP_036021489.1  SUN domain-containing protein 1 isoform X8

      Conserved Domains (4) summary
      pfam07738
      Location:777 → 911
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:92 → 416
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:709 → 734
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21439
      Location:554 → 605
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    5. XM_017321162.3 → XP_017176651.1  SUN domain-containing protein 1 isoform X6

      Conserved Domains (4) summary
      pfam07738
      Location:778 → 912
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:506 → 669
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 416
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:710 → 735
      Sun2_CC2; SUN2 coiled coil domain 2

    6. XM_017321164.3 → XP_017176653.1  SUN domain-containing protein 1 isoform X10

      Conserved Domains (4) summary
      pfam07738
      Location:756 → 890
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:484 → 647
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 394
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:688 → 713
      Sun2_CC2; SUN2 coiled coil domain 2

    7. XM_030254889.2 → XP_030110749.1  SUN domain-containing protein 1 isoform X3

      Conserved Domains (4) summary
      pfam07738
      Location:805 → 939
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:534 → 696
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 250
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:737 → 762
      Sun2_CC2; SUN2 coiled coil domain 2

    8. XM_017321165.3 → XP_017176654.1  SUN domain-containing protein 1 isoform X11

      Conserved Domains (4) summary
      pfam07738
      Location:751 → 885
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:479 → 642
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 389
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:683 → 708
      Sun2_CC2; SUN2 coiled coil domain 2

    9. XM_017321168.3 → XP_017176657.1  SUN domain-containing protein 1 isoform X13

      Conserved Domains (4) summary
      pfam07738
      Location:714 → 848
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:442 → 605
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 352
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:646 → 671
      Sun2_CC2; SUN2 coiled coil domain 2

    10. XM_017321163.3 → XP_017176652.1  SUN domain-containing protein 1 isoform X9

      Conserved Domains (4) summary
      pfam07738
      Location:768 → 902
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:497 → 659
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 407
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:700 → 725
      Sun2_CC2; SUN2 coiled coil domain 2

    11. XM_030254894.2 → XP_030110754.1  SUN domain-containing protein 1 isoform X16

      Conserved Domains (4) summary
      pfam07738
      Location:691 → 825
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:420 → 582
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 330
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:623 → 648
      Sun2_CC2; SUN2 coiled coil domain 2

    12. XM_030254890.2 → XP_030110750.1  SUN domain-containing protein 1 isoform X12

      Conserved Domains (4) summary
      pfam07738
      Location:747 → 881
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:475 → 638
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 385
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:679 → 704
      Sun2_CC2; SUN2 coiled coil domain 2

    13. XM_017321170.3 → XP_017176659.1  SUN domain-containing protein 1 isoform X15

      Conserved Domains (4) summary
      pfam07738
      Location:692 → 826
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:420 → 583
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 330
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:624 → 649
      Sun2_CC2; SUN2 coiled coil domain 2

    14. XM_017321171.3 → XP_017176660.1  SUN domain-containing protein 1 isoform X18

      Conserved Domains (4) summary
      pfam07738
      Location:659 → 793
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:387 → 550
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 297
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:591 → 616
      Sun2_CC2; SUN2 coiled coil domain 2

    15. XM_017321169.3 → XP_017176658.1  SUN domain-containing protein 1 isoform X14

      Conserved Domains (4) summary
      pfam07738
      Location:704 → 838
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:433 → 595
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 343
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:636 → 661
      Sun2_CC2; SUN2 coiled coil domain 2

    16. XM_036165597.1 → XP_036021490.1  SUN domain-containing protein 1 isoform X17

      Conserved Domains (4) summary
      pfam07738
      Location:682 → 816
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:92 → 321
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:614 → 639
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21439
      Location:459 → 510
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    17. XM_006504767.4 → XP_006504830.1  SUN domain-containing protein 1 isoform X19

      Conserved Domains (4) summary
      pfam07738
      Location:650 → 784
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:378 → 541
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:102 → 288
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:582 → 607
      Sun2_CC2; SUN2 coiled coil domain 2

    18. XM_036165595.1 → XP_036021488.1  SUN domain-containing protein 1 isoform X7

      UniProtKB/Swiss-Prot
      D3Z0V9, Q3TIW3, Q3TV96, Q6B4H0, Q80SU8, Q8BZ99, Q99P23, Q9D666
      Conserved Domains (5) summary
      COG1196
      Location:486 → 665
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:777 → 911
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:63 → 415
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:709 → 734
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21439
      Location:553 → 606
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    19. XM_017321160.2 → XP_017176649.1  SUN domain-containing protein 1 isoform X5

      Conserved Domains (4) summary
      pfam07738
      Location:786 → 920
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:514 → 677
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:73 → 230
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:718 → 743
      Sun2_CC2; SUN2 coiled coil domain 2

    20. XM_017321159.2 → XP_017176648.1  SUN domain-containing protein 1 isoform X5

      Conserved Domains (4) summary
      pfam07738
      Location:786 → 920
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:514 → 677
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:73 → 230
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:718 → 743
      Sun2_CC2; SUN2 coiled coil domain 2

    21. XM_017321161.2 → XP_017176650.1  SUN domain-containing protein 1 isoform X5

      Conserved Domains (4) summary
      pfam07738
      Location:786 → 920
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:514 → 677
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:73 → 230
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:718 → 743
      Sun2_CC2; SUN2 coiled coil domain 2

    22. XM_030254895.2 → XP_030110755.1  SUN domain-containing protein 1 isoform X20

      Conserved Domains (4) summary
      pfam07738
      Location:629 → 763
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:358 → 520
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:82 → 268
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:561 → 586
      Sun2_CC2; SUN2 coiled coil domain 2

    23. XM_030254897.2 → XP_030110757.1  SUN domain-containing protein 1 isoform X21

      Conserved Domains (4) summary
      pfam07738
      Location:620 → 754
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:349 → 511
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:73 → 259
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:552 → 577
      Sun2_CC2; SUN2 coiled coil domain 2

    24. XM_017321158.1 → XP_017176647.1  SUN domain-containing protein 1 isoform X4

      Conserved Domains (4) summary
      pfam07738
      Location:795 → 929
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam07888
      Location:523 → 686
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam09387
      Location:82 → 239
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:727 → 752
      Sun2_CC2; SUN2 coiled coil domain 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D666.2 GenPept UniProtKB/Swiss-Prot:Q9D666

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