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    Hectd3 HECT domain E3 ubiquitin protein ligase 3 [ Mus musculus (house mouse) ]

    Gene ID: 76608, updated on 28-Jun-2021

    Summary

    Official Symbol
    Hectd3provided by MGI
    Official Full Name
    HECT domain E3 ubiquitin protein ligase 3provided by MGI
    Primary source
    MGI:MGI:1923858
    See related
    Ensembl:ENSMUSG00000046861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI467540; AW743312; 1700064K09Rik
    Expression
    Ubiquitous expression in duodenum adult (RPKM 36.0), small intestine adult (RPKM 35.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Hectd3 in Genome Data Viewer
    Location:
    4; 4 D1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116852491..116862474)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116995296..117005277)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (116667953..116677882)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger SWIM-type containing 5 Neighboring gene general transcription factor IIB pseudogene Neighboring gene uroporphyrinogen decarboxylase Neighboring gene tetraspanin 17 pseudogene Neighboring gene eukaryotic translation initiation factor 2B, subunit 3 Neighboring gene predicted gene, 22335

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase HECTD3
    Names
    HECT domain-containing protein 3
    HECT-type E3 ubiquitin transferase HECTD3
    probable E3 ubiquitin-protein ligase HECTD3
    NP_780453.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175244.4NP_780453.1  E3 ubiquitin-protein ligase HECTD3

      See identical proteins and their annotated locations for NP_780453.1

      Status: VALIDATED

      Source sequence(s)
      AL671671, BC070411
      Consensus CDS
      CCDS18522.1
      UniProtKB/Swiss-Prot
      Q3U487
      Related
      ENSMUSP00000051922.10, ENSMUST00000050067.10
      Conserved Domains (3) summary
      cd08666
      Location:238371
      APC10-HECTD3; APC10-like DOC1 domain of HECTD3, a HECT E3 ubiquitin ligase protein that mediates substrate ubiquitination
      smart00119
      Location:528849
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00632
      Location:586845
      HECT; HECT-domain (ubiquitin-transferase)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116852491..116862474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001784215.3 RNA Sequence

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