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HECTD3 HECT domain E3 ubiquitin protein ligase 3 [ Homo sapiens (human) ]

Gene ID: 79654, updated on 4-Oct-2020

Summary

Official Symbol
HECTD3provided by HGNC
Official Full Name
HECT domain E3 ubiquitin protein ligase 3provided by HGNC
Primary source
HGNC:HGNC:26117
See related
Ensembl:ENSG00000126107 MIM:618638
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in duodenum (RPKM 25.9), small intestine (RPKM 22.6) and 25 other tissues See more
Orthologs

Genomic context

See HECTD3 in Genome Data Viewer
Location:
1p34.1
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (45002547..45011324, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45468220..45477027, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 35 Neighboring gene mitochondrial ribosomal protein S17 pseudogene 1 Neighboring gene zinc finger SWIM-type containing 5 Neighboring gene uroporphyrinogen decarboxylase Neighboring gene oligosaccharyltransferase complex subunit pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21156, FLJ31983, MGC161630

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase HECTD3
Names
HECT domain containing E3 ubiquitin protein ligase 3
HECT-type E3 ubiquitin transferase HECTD3
NP_078878.3
XP_024305571.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033058.1 RefSeqGene

    Range
    5032..13808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024602.6NP_078878.3  E3 ubiquitin-protein ligase HECTD3

    See identical proteins and their annotated locations for NP_078878.3

    Status: REVIEWED

    Source sequence(s)
    AK056545, AK056873, AK096462, AL359473, DA332198
    Consensus CDS
    CCDS41318.1
    UniProtKB/Swiss-Prot
    Q5T447
    UniProtKB/TrEMBL
    A1A4G1, B3KU34
    Related
    ENSP00000361245.4, ENST00000372172.5
    Conserved Domains (2) summary
    cd08666
    Location:238371
    APC10-HECTD3; APC10-like DOC1 domain of HECTD3, a HECT E3 ubiquitin ligase protein that mediates substrate ubiquitination
    pfam00632
    Location:579845
    HECT; HECT-domain (ubiquitin-transferase)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    45002547..45011324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449803.1XP_024305571.1  E3 ubiquitin-protein ligase HECTD3 isoform X1

    Conserved Domains (2) summary
    pfam00632
    Location:302561
    HECT; HECT-domain (ubiquitin-transferase)
    cl02148
    Location:187
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
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