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    Xpo6 exportin 6 [ Mus musculus (house mouse) ]

    Gene ID: 74204, updated on 23-Jun-2021

    Summary

    Official Symbol
    Xpo6provided by MGI
    Official Full Name
    exportin 6provided by MGI
    Primary source
    MGI:MGI:2429950
    See related
    Ensembl:ENSMUSG00000000131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ran; exp6; R75304; Ranbp20; AL022631; mKIAA0370; 2610005L19Rik; C230091E20Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 61.3), thymus adult (RPKM 29.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Xpo6 in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125700890..125799715, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126101718..126200539, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (133245232..133343922, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene katanin interacting protein Neighboring gene VISTA enhancer mm174 Neighboring gene GSG1-like Neighboring gene predicted gene, 51456 Neighboring gene LAG1 homolog, ceramide synthase 2 pseudogene Neighboring gene RIKEN cDNA 1700123J17 gene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    exportin-6
    Names
    RAN binding protein 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311143.2NP_001298072.1  exportin-6 isoform 1

      See identical proteins and their annotated locations for NP_001298072.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC012297, AC135809
      Consensus CDS
      CCDS80800.1
      UniProtKB/Swiss-Prot
      Q924Z6
      Related
      ENSMUSP00000130527.2, ENSMUST00000168189.8
      Conserved Domains (2) summary
      smart00913
      Location:3196
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:103277
      Xpo1; Exportin 1-like protein
    2. NM_028816.3NP_083092.2  exportin-6 isoform 2

      See identical proteins and their annotated locations for NP_083092.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC135809, BC058090, BU708634
      Consensus CDS
      CCDS52396.1
      UniProtKB/Swiss-Prot
      Q924Z6
      Related
      ENSMUSP00000009344.10, ENSMUST00000009344.16
      Conserved Domains (2) summary
      smart00913
      Location:3196
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:103277
      Xpo1; Exportin 1-like protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      125700890..125799715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312342.3XP_017167831.1  exportin-6 isoform X2

      Conserved Domains (2) summary
      smart00913
      Location:3196
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:103277
      Xpo1; Exportin 1-like protein
    2. XM_017312341.3XP_017167830.1  exportin-6 isoform X1

      Conserved Domains (2) summary
      smart00913
      Location:3196
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:103277
      Xpo1; Exportin 1-like protein
    3. XM_006508250.2XP_006508313.1  exportin-6 isoform X4

    4. XM_036153494.1XP_036009387.1  exportin-6 isoform X5

    5. XM_036153493.1XP_036009386.1  exportin-6 isoform X3

    6. XM_017312345.3XP_017167834.1  exportin-6 isoform X6

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