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XPO6 exportin 6 [ Homo sapiens (human) ]

Gene ID: 23214, updated on 3-Oct-2018

Summary

Official Symbol
XPO6provided by HGNC
Official Full Name
exportin 6provided by HGNC
Primary source
HGNC:HGNC:19733
See related
Ensembl:ENSG00000169180 MIM:608411; Vega:OTTHUMG00000176782
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EXP6; RANBP20
Summary
The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in testis (RPKM 30.3), spleen (RPKM 24.2) and 25 other tissues See more
Orthologs

Genomic context

See XPO6 in Genome Data Viewer
Location:
16p12.1
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (28097976..28212031, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28109297..28223281, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene GSG1 like Neighboring gene RNA, U6 small nuclear 159, pseudogene Neighboring gene RNA, U6 small nuclear 1241, pseudogene Neighboring gene TP53RK binding protein pseudogene 2 Neighboring gene RNY1 pseudogene 10 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 35 Neighboring gene SH3 domain binding kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22519, KIAA0370

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ran GTPase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IC
Inferred by Curator
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
exportin-6
Names
ran-binding protein 20

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270940.1NP_001257869.1  exportin-6 isoform 1

    See identical proteins and their annotated locations for NP_001257869.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform (1).
    Source sequence(s)
    AB002368, AK026172, AK123846, AY026388, BI465054, BX346769
    Consensus CDS
    CCDS59266.1
    UniProtKB/Swiss-Prot
    Q96QU8
    Related
    ENSP00000457341.1, OTTHUMP00000255086, ENST00000565698.5, OTTHUMT00000433731
    Conserved Domains (2) summary
    smart00913
    Location:1782
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:89263
    Xpo1; Exportin 1-like protein
  2. NM_015171.3NP_055986.1  exportin-6 isoform 2

    See identical proteins and their annotated locations for NP_055986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AB002368, AK026172, AY026388, BI465054, BX346769
    Consensus CDS
    CCDS42135.1
    UniProtKB/Swiss-Prot
    Q96QU8
    Related
    ENSP00000302790.4, OTTHUMP00000255087, ENST00000304658.9, OTTHUMT00000433732
    Conserved Domains (2) summary
    smart00913
    Location:3196
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:103277
    Xpo1; Exportin 1-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    28097976..28212031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450212.1XP_024305980.1  exportin-6 isoform X1

    Conserved Domains (2) summary
    smart00913
    Location:1782
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:89263
    Xpo1; Exportin 1-like protein
  2. XM_024450213.1XP_024305981.1  exportin-6 isoform X1

    Conserved Domains (2) summary
    smart00913
    Location:1782
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:89263
    Xpo1; Exportin 1-like protein
  3. XM_024450214.1XP_024305982.1  exportin-6 isoform X2

  4. XM_005255198.2XP_005255255.1  exportin-6 isoform X2

  5. XM_005255199.2XP_005255256.1  exportin-6 isoform X3

  6. XM_024450215.1XP_024305983.1  exportin-6 isoform X4

  7. XM_011545772.2XP_011544074.1  exportin-6 isoform X5

    Conserved Domains (2) summary
    smart00913
    Location:3196
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:103253
    Xpo1; Exportin 1-like protein
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